Inhibitory effects of various flavonoids isolated from leaves of persimmon on angiotensin-converting enzyme activity

Kenji Kameda, Takeshi Takaku, Hiromichi Okuda, Yoshiyuki Kimura, Takuo Okuda, Tsutomu Hatano, Isao Agata, Shigeru Arichi

Research output: Contribution to journalArticle

119 Citations (Scopus)

Abstract

The leaves of the persimmon Diospyros kaki, have been traditionally used for treatment of hypertensive diseases in Japan. We have studied the inhibitory effects of four flavonoids isolated from the leaves of the persimmon on angiotensin-converting enzyme activity. The four flavonoids astragalin [1], kaempferol-3-0-(2“-0-galloyl)-glucoside [2], isoquercitrin {31, and quercetin-3-0-(2“-0-galloyl)-glucoside [4] inhibited the angiotensin-converting enzyme activity in a dose-dependent fashion. Compounds 1-4produced 67%, 53%, 33%, and 48% inhibition at a concentration of 300 p-g/ml, respectively. The 50% inhibitory concentrations (IC50) of 1 and 2 for the angiotensin-converting enzyme were 180 p-g/ml and 280 p-g/ml, respectively. On the other hand, 2 and 4 were shown to have tannin activities, but 1 and 3 had no tannin activities. These results suggest that there is no relationship between the inhibition for angiotensin converting enzyme activity and the tannin activity for the four flavonoids.

Original languageEnglish
Pages (from-to)680-683
Number of pages4
JournalJournal of Natural Products
Volume50
Issue number4
DOIs
Publication statusPublished - Jul 1 1987

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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