Inhibitory effects of propolis granular A. P. C on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in A/J mice

Yukio Sugimoto, Yoshinori Iba, Ryoji Kayasuga, Yasushi Kirino, Miyuki Nishiga, Maria Alejandra Hossen, Kiyoshi Okihara, Hiroyuki Sugimoto, Hideo Yamada, Chiaki Kamei

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13 Citations (Scopus)

Abstract

We examined the effect of propolis granular A. P. C on lung tumorigenesis in female A/J mice. Lung tumors were induced by the tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) administered in drinking water for 7 weeks in mice maintained on an AIN-76A semi-synthetic diet. Propolis granular A. P. C (100 mg/kg body wt.) was administered orally daily for 6 days/week from 1 week before NNK administration and throughout the experiment. Sixteen weeks after the NNK treatment, the mice were killed and the number of surface lung tumors was measured. The number of lung tumors in mice treated with NNK alone for 7 weeks (9.4 mg/mouse) was significantly more than in that observed in control mice. Propolis granular A. P. C significantly decreased the number of lung tumors induced by NNK. These results indicate that propolis granular A. P. C is effective in suppressing NNK-induced lung tumorigenesis in mice.

Original languageEnglish
Pages (from-to)155-159
Number of pages5
JournalCancer Letters
Volume193
Issue number2
DOIs
Publication statusPublished - Apr 25 2003

Keywords

  • 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone
  • Artepillin C
  • Propolis

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Sugimoto, Y., Iba, Y., Kayasuga, R., Kirino, Y., Nishiga, M., Hossen, M. A., Okihara, K., Sugimoto, H., Yamada, H., & Kamei, C. (2003). Inhibitory effects of propolis granular A. P. C on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in A/J mice. Cancer Letters, 193(2), 155-159. https://doi.org/10.1016/S0304-3835(03)00016-8