Inhibitory Effects of Prior Low Dose X-Ray Irradiation on Fe3+-NTA-Induced Hepatopathy in Rats

Kiyonori Yamaoka, Takaharu Nomura, Keiji Iriyama, Shuji Kojima

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Blood activities of hepatocellular enzymes such as laclate dehydrogenase (LDH), glutamic pyruvic transaminase (GPT) and glutamic oxalacetic transaminase (GOT) peaked at 12 hours after a single intraabdominal injection of ferric nitrilotriacetate (Fe3+-NTA) in rats. Enzymes such as alkaline phosphatase (ALP) and leucin amino peptidase (LAP) originating in the capillary bile ducts or bile secretory liver cells were also released into the blood between 6-24 hours after intraabdominal injection of Fe3+-NTA in rats. Furthermore, hyperoxidation of lipids occurred in rat hepatic cell membranes, reaching a peak 6 hours after intraabdominal injection of Fe3+-NTA. It was found that a single prior 0.5 Gy whole body X-ray irradiation significantly increased superoxide dismutase (SOD) activities and suppressed above-mentioned symptoms of transient hepatopathy in rats.

Original languageEnglish
Pages (from-to)15-23
Number of pages9
JournalPhysiological chemistry and physics and medical NMR
Volume30
Issue number1
Publication statusPublished - Dec 1 1998

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Physiology
  • Spectroscopy

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