Inhibitory Effects of Prior Low Dose X-Ray Irradiation on Fe3+-NTA-Induced Hepatopathy in Rats

Kiyonori Yamaoka; Takaharu Nomura; Keiji Iriyama; Shuji Kojima

Inhibitory Effects of Prior Low Dose X-Ray Irradiation on Fe³⁺-NTA-Induced Hepatopathy in Rats

Kiyonori Yamaoka, Takaharu Nomura, Keiji Iriyama, Shuji Kojima

Research output: Contribution to journal › Article › peer-review

Abstract

Blood activities of hepatocellular enzymes such as laclate dehydrogenase (LDH), glutamic pyruvic transaminase (GPT) and glutamic oxalacetic transaminase (GOT) peaked at 12 hours after a single intraabdominal injection of ferric nitrilotriacetate (Fe³⁺-NTA) in rats. Enzymes such as alkaline phosphatase (ALP) and leucin amino peptidase (LAP) originating in the capillary bile ducts or bile secretory liver cells were also released into the blood between 6-24 hours after intraabdominal injection of Fe³⁺-NTA in rats. Furthermore, hyperoxidation of lipids occurred in rat hepatic cell membranes, reaching a peak 6 hours after intraabdominal injection of Fe³⁺-NTA. It was found that a single prior 0.5 Gy whole body X-ray irradiation significantly increased superoxide dismutase (SOD) activities and suppressed above-mentioned symptoms of transient hepatopathy in rats.

Original language	English
Pages (from-to)	15-23
Number of pages	9
Journal	Physiological chemistry and physics and medical NMR
Volume	30
Issue number	1
Publication status	Published - Dec 1 1998
Externally published	Yes

ASJC Scopus subject areas

Biophysics
Biochemistry
Physiology
Spectroscopy

Cite this

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title = "Inhibitory Effects of Prior Low Dose X-Ray Irradiation on Fe3+-NTA-Induced Hepatopathy in Rats",

abstract = "Blood activities of hepatocellular enzymes such as laclate dehydrogenase (LDH), glutamic pyruvic transaminase (GPT) and glutamic oxalacetic transaminase (GOT) peaked at 12 hours after a single intraabdominal injection of ferric nitrilotriacetate (Fe3+-NTA) in rats. Enzymes such as alkaline phosphatase (ALP) and leucin amino peptidase (LAP) originating in the capillary bile ducts or bile secretory liver cells were also released into the blood between 6-24 hours after intraabdominal injection of Fe3+-NTA in rats. Furthermore, hyperoxidation of lipids occurred in rat hepatic cell membranes, reaching a peak 6 hours after intraabdominal injection of Fe3+-NTA. It was found that a single prior 0.5 Gy whole body X-ray irradiation significantly increased superoxide dismutase (SOD) activities and suppressed above-mentioned symptoms of transient hepatopathy in rats.",

author = "Kiyonori Yamaoka and Takaharu Nomura and Keiji Iriyama and Shuji Kojima",

year = "1998",

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T1 - Inhibitory Effects of Prior Low Dose X-Ray Irradiation on Fe3+-NTA-Induced Hepatopathy in Rats

AU - Yamaoka, Kiyonori

AU - Nomura, Takaharu

AU - Iriyama, Keiji

AU - Kojima, Shuji

PY - 1998/12/1

Y1 - 1998/12/1

N2 - Blood activities of hepatocellular enzymes such as laclate dehydrogenase (LDH), glutamic pyruvic transaminase (GPT) and glutamic oxalacetic transaminase (GOT) peaked at 12 hours after a single intraabdominal injection of ferric nitrilotriacetate (Fe3+-NTA) in rats. Enzymes such as alkaline phosphatase (ALP) and leucin amino peptidase (LAP) originating in the capillary bile ducts or bile secretory liver cells were also released into the blood between 6-24 hours after intraabdominal injection of Fe3+-NTA in rats. Furthermore, hyperoxidation of lipids occurred in rat hepatic cell membranes, reaching a peak 6 hours after intraabdominal injection of Fe3+-NTA. It was found that a single prior 0.5 Gy whole body X-ray irradiation significantly increased superoxide dismutase (SOD) activities and suppressed above-mentioned symptoms of transient hepatopathy in rats.

AB - Blood activities of hepatocellular enzymes such as laclate dehydrogenase (LDH), glutamic pyruvic transaminase (GPT) and glutamic oxalacetic transaminase (GOT) peaked at 12 hours after a single intraabdominal injection of ferric nitrilotriacetate (Fe3+-NTA) in rats. Enzymes such as alkaline phosphatase (ALP) and leucin amino peptidase (LAP) originating in the capillary bile ducts or bile secretory liver cells were also released into the blood between 6-24 hours after intraabdominal injection of Fe3+-NTA in rats. Furthermore, hyperoxidation of lipids occurred in rat hepatic cell membranes, reaching a peak 6 hours after intraabdominal injection of Fe3+-NTA. It was found that a single prior 0.5 Gy whole body X-ray irradiation significantly increased superoxide dismutase (SOD) activities and suppressed above-mentioned symptoms of transient hepatopathy in rats.

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Inhibitory Effects of Prior Low Dose X-Ray Irradiation on Fe³⁺-NTA-Induced Hepatopathy in Rats

Abstract

ASJC Scopus subject areas

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