Inhibitory Effects of Prior Low Dose X-Ray Irradiation on Fe3+-NTA-Induced Hepatopathy in Rats

Kiyonori Yamaoka, Takaharu Nomura, Keiji Iriyama, Shuji Kojima

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Blood activities of hepatocellular enzymes such as laclate dehydrogenase (LDH), glutamic pyruvic transaminase (GPT) and glutamic oxalacetic transaminase (GOT) peaked at 12 hours after a single intraabdominal injection of ferric nitrilotriacetate (Fe3+-NTA) in rats. Enzymes such as alkaline phosphatase (ALP) and leucin amino peptidase (LAP) originating in the capillary bile ducts or bile secretory liver cells were also released into the blood between 6-24 hours after intraabdominal injection of Fe3+-NTA in rats. Furthermore, hyperoxidation of lipids occurred in rat hepatic cell membranes, reaching a peak 6 hours after intraabdominal injection of Fe3+-NTA. It was found that a single prior 0.5 Gy whole body X-ray irradiation significantly increased superoxide dismutase (SOD) activities and suppressed above-mentioned symptoms of transient hepatopathy in rats.

Original languageEnglish
Pages (from-to)15-23
Number of pages9
JournalPhysiological chemistry and physics and medical NMR
Volume30
Issue number1
Publication statusPublished - Dec 1 1998
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Physiology
  • Spectroscopy

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