Inhibitory effects of prior low-dose X-ray irradiation on carbon tetrachloride-induced hepatopathy in acatalasemic mice

Kiyonori Yamaoka, Takahiro Kataoka, Takaharu Nomura, Takehito Taguchi, Da Hong Wang, Shuji Mori, Katsumi Hanamoto, Shohei Kira

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The catalase activities in blood and organs of the acatalasemic (C3H/AnLCsbCsb) mouse of C3H strain are lower than those of the normal (C3H/AnLCsaCsa) mouse. We examined the effects of prior low-dose (0.5 Gy) X-ray irradiation, which reduced the oxidative damage under carbon tetrachloride-induced hepatopathy in the acatalasemic or normal mice. The acatalasemic mice showed a significantly lower catalase activity and a significantly higher glutathione peroxidase activity compared with those in the normal mice. Moreover, low-dose irradiation increased the catalase activity in the acatalasemic mouse liver to a level similar to that of the normal mouse liver. Pathological examinations and analyses of blood glutamic oxaloacetic and glutamic pyruvic transaminase activity and lipid peroxide levels showed that carbon tetrachloride induced hepatopathy was inhibited by low-dose irradiation. These findings may indicate that the free radical reaction induced by the lack of catalase and the administration of carbon tetrachloride is more properly neutralized by high glutathione peroxidase activity and low-dose irradiation in the acatalasemic mouse liver.

Original languageEnglish
Pages (from-to)89-95
Number of pages7
JournalJournal of Radiation Research
Volume45
Issue number1
DOIs
Publication statusPublished - Mar 2004

Fingerprint

carbon tetrachloride
Carbon Tetrachloride
mice
X-radiation
irradiation
X-Rays
catalase
dosage
Catalase
x rays
Inbred C3H Mouse
liver
Glutathione Peroxidase
glutathione
Liver
glutathione peroxidase
blood
Lipid Peroxides
Alanine Transaminase
Free Radicals

Keywords

  • Acatalasemic mouse
  • Antioxidant substances
  • Catalase
  • CCI
  • Hepatotoxicity
  • Low-dose X-irradiation

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Radiation

Cite this

Inhibitory effects of prior low-dose X-ray irradiation on carbon tetrachloride-induced hepatopathy in acatalasemic mice. / Yamaoka, Kiyonori; Kataoka, Takahiro; Nomura, Takaharu; Taguchi, Takehito; Wang, Da Hong; Mori, Shuji; Hanamoto, Katsumi; Kira, Shohei.

In: Journal of Radiation Research, Vol. 45, No. 1, 03.2004, p. 89-95.

Research output: Contribution to journalArticle

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