Inhibitory effects of prior low-dose X-irradiation on ischemia-reperfusion injury in mouse paw

Takahiro Kataoka, Yuko Mizuguchi, Masaaki Yoshimoto, Takehito Taguchi, Kiyonori Yamaoka

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

We have reported that low-dose, unlike high-dose, irradiation enhanced antioxidation function and reduced oxidative damage. On the other hand, ischemia-reperfusion injury is induced by reactive oxygen species. In this study, we examined the inhibitory effects of prior low-dose X-irradiation on ischemia-reperfusion injury in mouse paw. BALB/c mice were irradiated by sham or 0.5 Gy of X-ray. At 4 hrs after irradiation, the left hind leg was bound 10 times with a rubber ring for 0.5, 1, or 2 hrs and the paw thickness was measured. Results show that the paw swelling thickness by ischemia for 0.5 hr was lower than that for 2 hrs. At 1 hr after reperfusion from ischemia for 1 hr, superoxide dismutase activity in serum was increased in those mice which received 0.5 Gy irradiation and in the case of the ischemia for 0.5 or 1 hr, the paw swelling thicknesses were inhibited by 0.5 Gy irradiation. In addition, interstitial edema in those mice which received 0.5 Gy irradiation was less than that in the mice which underwent by sham irradiation. These findings suggest that the ischemia-reperfusion injury is inhibited by the enhancement of antioxidation function by 0.5 Gy irradiation.

Original languageEnglish
Pages (from-to)505-513
Number of pages9
JournalJournal of Radiation Research
Volume48
Issue number6
DOIs
Publication statusPublished - 2007

Fingerprint

ischemia
Reperfusion Injury
mice
irradiation
dosage
Ischemia
swelling
Rubber
Superoxide Dismutase
Reperfusion
Reactive Oxygen Species
Edema
Leg
edema
X-Rays
inorganic peroxides
rubber
serums
reactive oxygen species
legs

Keywords

  • Antioxidation function
  • Edema
  • Ischemia-reperfusion injury
  • Low-dose irradiation
  • Reactive oxygen species

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Radiation

Cite this

Inhibitory effects of prior low-dose X-irradiation on ischemia-reperfusion injury in mouse paw. / Kataoka, Takahiro; Mizuguchi, Yuko; Yoshimoto, Masaaki; Taguchi, Takehito; Yamaoka, Kiyonori.

In: Journal of Radiation Research, Vol. 48, No. 6, 2007, p. 505-513.

Research output: Contribution to journalArticle

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