Inhibitory effects of prior low-dose x-irradiation on cold-induced brain injury in mouse

Masaaki Yoshimoto, Takahiro Kataoka, Teruaki Toyota, Takehito Taguchi, Kiyonori Yamaoka

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

We examined the inhibitory effects of low-dose X-irradiation on mouse brain tissue with cold-induced injury by comparing tissue samples from three groups of mice: control, sham-irradiated cold-exposed, and X-ray-irradiated (0.5 Gy) cold-exposed mice. The water content in brain increased significantly in the sham-irradiated group following the cold-induced injury relative to the control group. However, water content in brain tissue from the X-ray-irradiated group was significantly lower than that from the sham-irradiated group. Levels of antioxidants, such as superoxide dismutase and glutathione, in brain tissue from the X-ray-irradiated group were higher than those from the sham-irradiated group. Moreover, the cold injury-induced cell death, particularly apoptosis, while low-dose irradiation inhibited cell death, especially among glial cells, but not numeral cells. These findings suggest that prior low-dose X-irradiation activated antioxidant function and inhibited cold-induced brain injury.

Original languageEnglish
Pages (from-to)89-97
Number of pages9
JournalInflammation
Volume35
Issue number1
DOIs
Publication statusPublished - Feb 2012

Fingerprint

Brain Injuries
X-Rays
Brain
Cell Death
Antioxidants
Control Groups
Water
Neuroglia
Superoxide Dismutase
Glutathione
Apoptosis
Cold Injury

Keywords

  • 0.5 Gy irradiation
  • Antioxidative function
  • Brain edema
  • Cold injury

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Inhibitory effects of prior low-dose x-irradiation on cold-induced brain injury in mouse. / Yoshimoto, Masaaki; Kataoka, Takahiro; Toyota, Teruaki; Taguchi, Takehito; Yamaoka, Kiyonori.

In: Inflammation, Vol. 35, No. 1, 02.2012, p. 89-97.

Research output: Contribution to journalArticle

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