Inhibitory effects of post low dose γ-ray irradiation on ferric- nitrilotriacetate-induced mice liver damage

Kiyonori Yamaoka, Shuji Kojima, Takaharu Nomura

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Abstract

We studied the effects of a single post whole-body low-dose irradiation (50 cGy of γ-ray) on mice with ferric nitrilotriacetate (Fe3+-NTA)-induced transient hepatopathy. As a result, low-dose irradiation accelerated the rate of recovery. Based on the changes in glutamic oxaloacetic transaminase (GOT) activities, glutamic pyruvic transaminase (GPT) activities and lipid peroxide levels, it was shown that hepatopathy was improved by low-dose irradiation 3 h after Fe3+ -NTA administration. This may be because of the enhancement of antioxidant agents such as total glutathione (GSH + GSSG), glutathione peroxidase (GPX), glutathione reductase (GR) and γ-glutamylcysteine synthetase (γ-GCS) by low-dose irradiation. These findings suggest that low- dose irradiation relieved functional disorders at least in the livers of mice with active oxygen species related diseases.

Original languageEnglish
Pages (from-to)213-221
Number of pages9
JournalFree Radical Research
Volume32
Issue number3
DOIs
Publication statusPublished - Jan 1 2000

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Keywords

  • Antioxidant
  • Fe-NTA
  • Hepatopathy
  • Lipid peroxide
  • Low-dose γ-irradiation

ASJC Scopus subject areas

  • Biochemistry

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