Inhibitory effects of post low dose γ-ray irradiation on ferric- nitrilotriacetate-induced mice liver damage

Kiyonori Yamaoka; Shuji Kojima; Takaharu Nomura

doi:10.1080/10715760000300221

Inhibitory effects of post low dose γ-ray irradiation on ferric- nitrilotriacetate-induced mice liver damage

Kiyonori Yamaoka, Shuji Kojima, Takaharu Nomura

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

We studied the effects of a single post whole-body low-dose irradiation (50 cGy of γ-ray) on mice with ferric nitrilotriacetate (Fe³⁺-NTA)-induced transient hepatopathy. As a result, low-dose irradiation accelerated the rate of recovery. Based on the changes in glutamic oxaloacetic transaminase (GOT) activities, glutamic pyruvic transaminase (GPT) activities and lipid peroxide levels, it was shown that hepatopathy was improved by low-dose irradiation 3 h after Fe³⁺ -NTA administration. This may be because of the enhancement of antioxidant agents such as total glutathione (GSH + GSSG), glutathione peroxidase (GPX), glutathione reductase (GR) and γ-glutamylcysteine synthetase (γ-GCS) by low-dose irradiation. These findings suggest that low- dose irradiation relieved functional disorders at least in the livers of mice with active oxygen species related diseases.

Original language	English
Pages (from-to)	213-221
Number of pages	9
Journal	Free Radical Research
Volume	32
Issue number	3
DOIs	https://doi.org/10.1080/10715760000300221
Publication status	Published - Jan 1 2000

Keywords

Antioxidant
Fe-NTA
Hepatopathy
Lipid peroxide
Low-dose γ-irradiation

ASJC Scopus subject areas

Biochemistry

Access to Document

10.1080/10715760000300221

Cite this

@article{f75a1d002ab04a5cbcde7b1f518b684b,

title = "Inhibitory effects of post low dose γ-ray irradiation on ferric- nitrilotriacetate-induced mice liver damage",

abstract = "We studied the effects of a single post whole-body low-dose irradiation (50 cGy of γ-ray) on mice with ferric nitrilotriacetate (Fe3+-NTA)-induced transient hepatopathy. As a result, low-dose irradiation accelerated the rate of recovery. Based on the changes in glutamic oxaloacetic transaminase (GOT) activities, glutamic pyruvic transaminase (GPT) activities and lipid peroxide levels, it was shown that hepatopathy was improved by low-dose irradiation 3 h after Fe3+ -NTA administration. This may be because of the enhancement of antioxidant agents such as total glutathione (GSH + GSSG), glutathione peroxidase (GPX), glutathione reductase (GR) and γ-glutamylcysteine synthetase (γ-GCS) by low-dose irradiation. These findings suggest that low- dose irradiation relieved functional disorders at least in the livers of mice with active oxygen species related diseases.",

keywords = "Antioxidant, Fe-NTA, Hepatopathy, Lipid peroxide, Low-dose γ-irradiation",

author = "Kiyonori Yamaoka and Shuji Kojima and Takaharu Nomura",

year = "2000",

month = jan,

day = "1",

doi = "10.1080/10715760000300221",

language = "English",

volume = "32",

pages = "213--221",

journal = "Free Radical Research",

issn = "1071-5762",

publisher = "Informa Healthcare",

number = "3",

}

TY - JOUR

T1 - Inhibitory effects of post low dose γ-ray irradiation on ferric- nitrilotriacetate-induced mice liver damage

AU - Yamaoka, Kiyonori

AU - Kojima, Shuji

AU - Nomura, Takaharu

PY - 2000/1/1

Y1 - 2000/1/1

N2 - We studied the effects of a single post whole-body low-dose irradiation (50 cGy of γ-ray) on mice with ferric nitrilotriacetate (Fe3+-NTA)-induced transient hepatopathy. As a result, low-dose irradiation accelerated the rate of recovery. Based on the changes in glutamic oxaloacetic transaminase (GOT) activities, glutamic pyruvic transaminase (GPT) activities and lipid peroxide levels, it was shown that hepatopathy was improved by low-dose irradiation 3 h after Fe3+ -NTA administration. This may be because of the enhancement of antioxidant agents such as total glutathione (GSH + GSSG), glutathione peroxidase (GPX), glutathione reductase (GR) and γ-glutamylcysteine synthetase (γ-GCS) by low-dose irradiation. These findings suggest that low- dose irradiation relieved functional disorders at least in the livers of mice with active oxygen species related diseases.

AB - We studied the effects of a single post whole-body low-dose irradiation (50 cGy of γ-ray) on mice with ferric nitrilotriacetate (Fe3+-NTA)-induced transient hepatopathy. As a result, low-dose irradiation accelerated the rate of recovery. Based on the changes in glutamic oxaloacetic transaminase (GOT) activities, glutamic pyruvic transaminase (GPT) activities and lipid peroxide levels, it was shown that hepatopathy was improved by low-dose irradiation 3 h after Fe3+ -NTA administration. This may be because of the enhancement of antioxidant agents such as total glutathione (GSH + GSSG), glutathione peroxidase (GPX), glutathione reductase (GR) and γ-glutamylcysteine synthetase (γ-GCS) by low-dose irradiation. These findings suggest that low- dose irradiation relieved functional disorders at least in the livers of mice with active oxygen species related diseases.

KW - Antioxidant

KW - Fe-NTA

KW - Hepatopathy

KW - Lipid peroxide

KW - Low-dose γ-irradiation

UR - http://www.scopus.com/inward/record.url?scp=0034011358&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034011358&partnerID=8YFLogxK

U2 - 10.1080/10715760000300221

DO - 10.1080/10715760000300221

M3 - Article

C2 - 10730820

AN - SCOPUS:0034011358

SN - 1071-5762

VL - 32

SP - 213

EP - 221

JO - Free Radical Research

JF - Free Radical Research

IS - 3

ER -

Inhibitory effects of post low dose γ-ray irradiation on ferric- nitrilotriacetate-induced mice liver damage

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this