Inhibitory effects of Korean medicinal plants and camelliatannin H from Camellia japonica on human immunodeficiency virus type 1 protease

Jong Cheol Park, Jong Moon Hur, Ju Gwon Park, Tsutomu Hatano, Takashi Yoshida, Hirotsugu Miyashiro, Byung Sun Min, Masao Hattori

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To identify substances with anti-human immunodeficiency virus (HIV) activity in traditional medicines, 101 extracts of Korean medicinal plants were screened for their inhibitory effects on HIV type 1 protease (PR). The enzyme activity was determined by HPLC. Of the extracts tested, strong inhibitory effects were observed in the acetone extracts of the pericarp and leaves of Camellia japonica, the water extract of the leaves of Sageretia theezans and the methanol extract of the aerial part of Sophora flavescens. Camelliatannin H from the pericarp of C. japonica, showed a potent inhibitory activity on HIV-1 PR with IC50 of 0.9 μM.

Original languageEnglish
Pages (from-to)422-426
Number of pages5
JournalPhytotherapy Research
Issue number5
Publication statusPublished - Aug 2002



  • Camellia japonica L.
  • Camelliatannin H
  • HIV-1 protease
  • Korean medicinal plants
  • Protease inhibitor

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

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