Inhibitory Effects of Escherichia coli on the Formation and Development of Staphylococcus epidermidis Biofilm

Han Min Ohn, Tamaki Mizuno, Shin Ichi Miyoshi

Research output: Contribution to journalArticlepeer-review

Abstract

In the present study, we examined whether a commensal gut bacterium Escherichia coli might prevent the formation and development of the biofilm of Staphylococcus epidermidis, a nosocomial extraintestinal pathogen but not a gut microorganism. When co-cultured with S. epidermidis, E. coli strain ATCC 35218, a non-pathogenic strain, was found to be dominant in the biofilm formed on the surface of wells of a microtiter plate. In addition, E. coli significantly incorporated and grew in a niche preoccupied by S. epidermidis biofilm. Two other E. coli strains (strain K-12 and B) also showed to interfere the biofilm formation by S. epidermidis. In contrast, S. epidermidis could not grow in a niche preoccupied by E. coli biofilm. These results suggest that, through inhibition of the formation and development of the biofilm, E. coli may eliminate S. epidermidis from the gastrointestinal tract.

Original languageEnglish
Pages (from-to)113-118
Number of pages6
JournalBiocontrol science
Volume26
Issue number2
DOIs
Publication statusPublished - 2021

Keywords

  • Biofilm
  • Escherichia coli
  • Staphylococcus epidermidis

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Public Health, Environmental and Occupational Health

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