Inhibitory effects of beer and other alcoholic beverages on mutagenesis and DNA adduct formation induced by several carcinogens

Sakae Arimoto, Chitose Sugiyama, Nanaho Harada, Miyuki Takeuchi, Miyuki Takemura, Hikoya Hayatsu

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

The possibility that beer and other alcoholic beverages could be antimutagenic against the heterocyclic amines (HAs), a group of carcinogens produced on cooking proteinaceous foods, has been explored. In the Salmonella mutation assays, beer showed inhibitory effects against several HAs [preactivated Trp-P-1, Trp-P-2(NHOH), and Glu-P-1(NHOH)] that are directly mutagenic in bacteria. Japanese sake, red and white wines, and brandy were also effective. However, ethyl alcohol alone did not show these effects. The formation of O6-methylguanine by N-methyl-N'-nitro-N-nitrosoguanidine in the DNA of Salmonella YG7108 was also inhibited by beer. Nonvolatile beer components were administered orally to CDF1 mice together with Trp-P-2. Adducts in the liver DNA were significantly decreased by the beer, as compared to those in controls fed Trp-P-2 only. Although several phenolic compounds known to be present in beer were antimutagenic toward these mutagens, their effects were very small. It was concluded that some yet to be identified component(s) of beer is (are) responsible for this antimutagenicity.

Original languageEnglish
Pages (from-to)221-230
Number of pages10
JournalJournal of Agricultural and Food Chemistry
Volume47
Issue number1
DOIs
Publication statusPublished - Jan 1999

Fingerprint

DNA adducts
Beer
Alcoholic Beverages
Mutagenesis
alcoholic beverages
DNA Adducts
carcinogens
beers
mutagenesis
Carcinogens
heterocyclic amines
Salmonella
2-amino-6-methyldipyrido(1,2-a-3',2'-d)imidazole
Amines
brandy
Methylnitronitrosoguanidine
sake
Wine
white wines
DNA

Keywords

  • Alcoholic beverages
  • Antimutagenicity
  • Beer
  • DNA adducts
  • Food pyrolysate mutagens
  • Plant phenols

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Food Science
  • Chemistry (miscellaneous)

Cite this

Inhibitory effects of beer and other alcoholic beverages on mutagenesis and DNA adduct formation induced by several carcinogens. / Arimoto, Sakae; Sugiyama, Chitose; Harada, Nanaho; Takeuchi, Miyuki; Takemura, Miyuki; Hayatsu, Hikoya.

In: Journal of Agricultural and Food Chemistry, Vol. 47, No. 1, 01.1999, p. 221-230.

Research output: Contribution to journalArticle

Arimoto, Sakae ; Sugiyama, Chitose ; Harada, Nanaho ; Takeuchi, Miyuki ; Takemura, Miyuki ; Hayatsu, Hikoya. / Inhibitory effects of beer and other alcoholic beverages on mutagenesis and DNA adduct formation induced by several carcinogens. In: Journal of Agricultural and Food Chemistry. 1999 ; Vol. 47, No. 1. pp. 221-230.
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