Inhibitory effect of saturated fatty acids on the mutagenicity of N-nitrosodimethylamine

Tomoe Negishi, Hikoya Hayatsu

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Saturated fatty acids, C5C12, inhibited the mutagenic activity of N-nitrosodimethylamine (NDMA) in E. coli WP2 uvrA/pKM101. The inhibition by laurate (C12) was due to the suppression of the enzymatic demethylation of NDMA, whereas that by caprate (C10) was simply due to the bactericidal effect of the fatty acid. Caproate (C6) did not affect the NDMA-demethylase, and evidence is presented to show that the inhibition of mutagenesis by caproate was a result of its interference with the uptake of NDMA metabolites into bacterial cells. Possible biological significance of the inhibition is discussed.

Original languageEnglish
Pages (from-to)87-96
Number of pages10
JournalMutation Research/Genetic Toxicology
Volume135
Issue number2
DOIs
Publication statusPublished - 1984

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Dimethylnitrosamine
Fatty Acids
Laurates
Cytochrome P-450 CYP2E1
Mutagenesis
Metabolites
Escherichia coli
hexanoic acid

ASJC Scopus subject areas

  • Genetics
  • Toxicology
  • Medicine(all)

Cite this

Inhibitory effect of saturated fatty acids on the mutagenicity of N-nitrosodimethylamine. / Negishi, Tomoe; Hayatsu, Hikoya.

In: Mutation Research/Genetic Toxicology, Vol. 135, No. 2, 1984, p. 87-96.

Research output: Contribution to journalArticle

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