Inhibitory effect of methyl ethyl ketone upon the enhancement of cerebral blood flow during status epilepticus induced by lithium-pilocarpine

Eriko Sugiyama, Yuina Matsuki, Sotaro Momosaki, Rie Hosoi, Nobuyoshi Hasebe, Koji Abe, Osamu Inoue

Research output: Contribution to journalArticle

Abstract

Significant increases in local cerebral blood flow during lithium-pilocarpine (Li-P) induced seizure have been reported. We recently found that both acetone and methyl ethyl ketone (MEK) showed anticonvulsive effects in status epilepticus induced by Li-P in rats. In this study, we examined whether MEK also suppressed the enhancement of local cerebral blood flow induced by Li-P with a simplified autoradiographic method using [14C]-para-iodo-N-isopropyl amphetamine ([14C]-IMP). Significant increases in local cerebral blood flow in the thalamus, hypothalamus, hippocampus and cerebellum were observed in Li-P induced status epilepticus rats. Pretreatment with MEK (8 mmol/kg) completely suppressed the enhancement of local cerebral blood flow to or below the control level in all regions.

Original languageEnglish
Pages (from-to)300-302
Number of pages3
JournalNeuroscience Letters
Volume462
Issue number3
DOIs
Publication statusPublished - Sep 25 2009
Externally publishedYes

Fingerprint

Cerebrovascular Circulation
Pilocarpine
Status Epilepticus
Lithium
Inosine Monophosphate
Amphetamine
Acetone
Thalamus
Cerebellum
Hypothalamus
Hippocampus
Seizures
methylethyl ketone

Keywords

  • Anticonvulsant
  • Cerebral blood flow
  • Methyl ethyl ketone
  • Pilocarpine
  • Seizure

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Inhibitory effect of methyl ethyl ketone upon the enhancement of cerebral blood flow during status epilepticus induced by lithium-pilocarpine. / Sugiyama, Eriko; Matsuki, Yuina; Momosaki, Sotaro; Hosoi, Rie; Hasebe, Nobuyoshi; Abe, Koji; Inoue, Osamu.

In: Neuroscience Letters, Vol. 462, No. 3, 25.09.2009, p. 300-302.

Research output: Contribution to journalArticle

Sugiyama, Eriko ; Matsuki, Yuina ; Momosaki, Sotaro ; Hosoi, Rie ; Hasebe, Nobuyoshi ; Abe, Koji ; Inoue, Osamu. / Inhibitory effect of methyl ethyl ketone upon the enhancement of cerebral blood flow during status epilepticus induced by lithium-pilocarpine. In: Neuroscience Letters. 2009 ; Vol. 462, No. 3. pp. 300-302.
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