Inhibitory effect of methyl ethyl ketone upon the enhancement of cerebral blood flow during status epilepticus induced by lithium-pilocarpine

Eriko Sugiyama, Yuina Matsuki, Sotaro Momosaki, Rie Hosoi, Nobuyoshi Hasebe, Kohji Abe, Osamu Inoue

Research output: Contribution to journalArticle

Abstract

Significant increases in local cerebral blood flow during lithium-pilocarpine (Li-P) induced seizure have been reported. We recently found that both acetone and methyl ethyl ketone (MEK) showed anticonvulsive effects in status epilepticus induced by Li-P in rats. In this study, we examined whether MEK also suppressed the enhancement of local cerebral blood flow induced by Li-P with a simplified autoradiographic method using [14C]-para-iodo-N-isopropyl amphetamine ([14C]-IMP). Significant increases in local cerebral blood flow in the thalamus, hypothalamus, hippocampus and cerebellum were observed in Li-P induced status epilepticus rats. Pretreatment with MEK (8 mmol/kg) completely suppressed the enhancement of local cerebral blood flow to or below the control level in all regions.

Original languageEnglish
Pages (from-to)300-302
Number of pages3
JournalNeuroscience Letters
Volume462
Issue number3
DOIs
Publication statusPublished - Sep 25 2009
Externally publishedYes

Keywords

  • Anticonvulsant
  • Cerebral blood flow
  • Methyl ethyl ketone
  • Pilocarpine
  • Seizure

ASJC Scopus subject areas

  • Neuroscience(all)

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