Inhibitory effect of isomaltodextrin on tyrosine metabolite production in rat gut microbiota

Ryodai Takagaki, Chiyo Yoshizane, Yuki Ishida, Takeo Sakurai, Yoshifumi Taniguchi, Hikaru Watanabe, Hitoshi Mitsuzumi, Shimpei Ushio, Hidetoshi Morita

Research output: Contribution to journalArticlepeer-review


We examined the effect of isomaltodextrin (IMD), a soluble dietary fiber, on production of putrefactive products by intestinal bacteria using a tyrosine load test to measure phenol production in IMD-treated rats. We observed a significant increase in phenol and p-cresol concentrations in rats administered with only tyrosine, but not for rats co-administered tyrosine and IMD. To elucidate the mechanism of this effect, we analyzed the intestinal microbiota in each group and found that although IMD had no direct effect on the proportion of bacteria known to produce phenols, it did alter the balance of intestinal microbiota. The results suggested that changes in the intestinal microbiota composition reduced the metabolic capacity for tyrosine and in turn suppressed production of phenol or p-cresol, putrefactive products in the intestine.

Original languageEnglish
Pages (from-to)824-831
Number of pages8
JournalBioscience, Biotechnology and Biochemistry
Issue number4
Publication statusPublished - Apr 2 2020


  • Dietary fiber
  • isomaltodextrin
  • phenol
  • prebiotics

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry


Dive into the research topics of 'Inhibitory effect of isomaltodextrin on tyrosine metabolite production in rat gut microbiota'. Together they form a unique fingerprint.

Cite this