TY - JOUR
T1 - Inhibitory effect of isomaltodextrin on tyrosine metabolite production in rat gut microbiota
AU - Takagaki, Ryodai
AU - Yoshizane, Chiyo
AU - Ishida, Yuki
AU - Sakurai, Takeo
AU - Taniguchi, Yoshifumi
AU - Watanabe, Hikaru
AU - Mitsuzumi, Hitoshi
AU - Ushio, Shimpei
AU - Morita, Hidetoshi
N1 - Funding Information:
We thank Okayama University Hospital Biobank (Okadai Biobank) for Illumina sequencing.
Publisher Copyright:
© 2019, © 2019 Japan Society for Bioscience, Biotechnology, and Agrochemistry.
PY - 2020/4/2
Y1 - 2020/4/2
N2 - We examined the effect of isomaltodextrin (IMD), a soluble dietary fiber, on production of putrefactive products by intestinal bacteria using a tyrosine load test to measure phenol production in IMD-treated rats. We observed a significant increase in phenol and p-cresol concentrations in rats administered with only tyrosine, but not for rats co-administered tyrosine and IMD. To elucidate the mechanism of this effect, we analyzed the intestinal microbiota in each group and found that although IMD had no direct effect on the proportion of bacteria known to produce phenols, it did alter the balance of intestinal microbiota. The results suggested that changes in the intestinal microbiota composition reduced the metabolic capacity for tyrosine and in turn suppressed production of phenol or p-cresol, putrefactive products in the intestine.
AB - We examined the effect of isomaltodextrin (IMD), a soluble dietary fiber, on production of putrefactive products by intestinal bacteria using a tyrosine load test to measure phenol production in IMD-treated rats. We observed a significant increase in phenol and p-cresol concentrations in rats administered with only tyrosine, but not for rats co-administered tyrosine and IMD. To elucidate the mechanism of this effect, we analyzed the intestinal microbiota in each group and found that although IMD had no direct effect on the proportion of bacteria known to produce phenols, it did alter the balance of intestinal microbiota. The results suggested that changes in the intestinal microbiota composition reduced the metabolic capacity for tyrosine and in turn suppressed production of phenol or p-cresol, putrefactive products in the intestine.
KW - Dietary fiber
KW - isomaltodextrin
KW - phenol
KW - prebiotics
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U2 - 10.1080/09168451.2019.1704618
DO - 10.1080/09168451.2019.1704618
M3 - Article
C2 - 31852406
AN - SCOPUS:85078636957
VL - 84
SP - 824
EP - 831
JO - Bioscience, Biotechnology and Biochemistry
JF - Bioscience, Biotechnology and Biochemistry
SN - 0916-8451
IS - 4
ER -