TY - JOUR
T1 - Inhibitory effect of iodophenpropit, a selective histamine H3 antagonist, on amygdaloid kindled seizures
AU - Harada, Chie
AU - Fujii, Yoko
AU - Hirai, Tadashi
AU - Shinomiya, Kazuaki
AU - Kamei, Chiaki
N1 - Funding Information:
This work was supported by Japan Epilepsy Research Foundation.
PY - 2004/3/15
Y1 - 2004/3/15
N2 - The effect of histamine H3 antagonist, iodophenpropit on amygdaloid kindled seizures in rats was studied in comparison with those of other H3 antagonists. Under pentobarbital anesthesia, the rats were fixed to a stereotaxic apparatus and bipolar electrodes were implanted into the amygdala. Electrodes were connected to a miniature receptacle, which was embedded in the skull with dental cement. To cause kindled seizures, electrical stimulation was applied to the amygdala bipolarly every day by a constant current stimulator, and electroencephalogram and convulsive behavior were observed. Drug effects were estimated in rats showing generalized kindled seizures. Intraperitoneal injection of H3 antagonists, iodophenpropit, thioperamide, AQ0145 and clobenpropit, resulted in a dose-related inhibition of amygdaloid kindled seizures. The effect of iodophenpropit on amygdaloid kindled seizures was more potent than those of thioperamide, AQ0145 and clobenpropit. In conclusion, iodophenpropit may be useful for the treatment of partial epilepsy and/or secondary generalized seizures in humans.
AB - The effect of histamine H3 antagonist, iodophenpropit on amygdaloid kindled seizures in rats was studied in comparison with those of other H3 antagonists. Under pentobarbital anesthesia, the rats were fixed to a stereotaxic apparatus and bipolar electrodes were implanted into the amygdala. Electrodes were connected to a miniature receptacle, which was embedded in the skull with dental cement. To cause kindled seizures, electrical stimulation was applied to the amygdala bipolarly every day by a constant current stimulator, and electroencephalogram and convulsive behavior were observed. Drug effects were estimated in rats showing generalized kindled seizures. Intraperitoneal injection of H3 antagonists, iodophenpropit, thioperamide, AQ0145 and clobenpropit, resulted in a dose-related inhibition of amygdaloid kindled seizures. The effect of iodophenpropit on amygdaloid kindled seizures was more potent than those of thioperamide, AQ0145 and clobenpropit. In conclusion, iodophenpropit may be useful for the treatment of partial epilepsy and/or secondary generalized seizures in humans.
KW - Amygdaloid kindled seizure
KW - Clobenpropit
KW - Iodophenpropit
KW - Rats
KW - Thioperamide
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U2 - 10.1016/j.brainresbull.2004.02.001
DO - 10.1016/j.brainresbull.2004.02.001
M3 - Article
C2 - 15130703
AN - SCOPUS:2342461051
VL - 63
SP - 143
EP - 146
JO - Journal of Electrophysiological Techniques
JF - Journal of Electrophysiological Techniques
SN - 0361-9230
IS - 2
ER -