Inhibitory effect of iodophenpropit, a selective histamine H3 antagonist, on amygdaloid kindled seizures

Chie Harada, Yoko Fujii, Tadashi Hirai, Kazuaki Shinomiya, Chiaki Kamei

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

The effect of histamine H3 antagonist, iodophenpropit on amygdaloid kindled seizures in rats was studied in comparison with those of other H3 antagonists. Under pentobarbital anesthesia, the rats were fixed to a stereotaxic apparatus and bipolar electrodes were implanted into the amygdala. Electrodes were connected to a miniature receptacle, which was embedded in the skull with dental cement. To cause kindled seizures, electrical stimulation was applied to the amygdala bipolarly every day by a constant current stimulator, and electroencephalogram and convulsive behavior were observed. Drug effects were estimated in rats showing generalized kindled seizures. Intraperitoneal injection of H3 antagonists, iodophenpropit, thioperamide, AQ0145 and clobenpropit, resulted in a dose-related inhibition of amygdaloid kindled seizures. The effect of iodophenpropit on amygdaloid kindled seizures was more potent than those of thioperamide, AQ0145 and clobenpropit. In conclusion, iodophenpropit may be useful for the treatment of partial epilepsy and/or secondary generalized seizures in humans.

Original languageEnglish
Pages (from-to)143-146
Number of pages4
JournalBrain Research Bulletin
Volume63
Issue number2
DOIs
Publication statusPublished - Mar 15 2004

Keywords

  • Amygdaloid kindled seizure
  • Clobenpropit
  • Iodophenpropit
  • Rats
  • Thioperamide

ASJC Scopus subject areas

  • Neuroscience(all)

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