Inhibitory effect of hemin on the mutagenic activities of carcinogens

Sakae Arimoto, T. Negishi, H. Hayatsu

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Abstract

An inhibitory effect of hemin on mutagenicities of a range of carcinogens was found by adding hemin to the preincubation mixture of the Ames' test. Strong inhibitions were observed for benzo[α]pyrene, 3-methylcholanthrene, 7,10-dimethylbenz[α]anthracene, chrysene, 2-acetylaminofluorene, 2-nitrofluorene and aflatoxin B1. Generally, 50% inhibition was caused by an amount of hemin 1-2 equivalents to the mutagen. Excess of hemin caused complete inhibitions. Hemin did not affect the mutagenicities of 2-(2-furyl)-3-(5-nitro-2-furyl) acrylamide, 4-nitroquinoline-1-oxide, nitromin, N-methyl-N-nitrosourea, N-methyl-N'-nitro-N-nitrosoguanidine, N-nitrosodi-n-butylamine, quinoxaline-1,4-dioxide and carbadox. Biliverdin, bilirubin and chlorophyllin were also effective as inhibitors for the mutagenicity of benzo[α]pyrene.

Original languageEnglish
Pages (from-to)29-33
Number of pages5
JournalCancer Letters
Volume11
Issue number1
Publication statusPublished - 1980

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ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

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