Inhibitory effect of 13 taxane diterpenoids from Chinese yew (Taxus chinensis var. mairei) on the proliferation of hela cervical cancer cells

Hai Sheng Liu, Yu Huan Gao, Li Hong Liu, Wei Liu, Qing Wen Shi, Mei Dong, Toshikazu Suzuki, Hiromasa Kiyota

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The inhibitory effect of 13 taxanes isolated from the Chinese yew (Taxus chinensis var. mairei) on the proliferation of human cervical cancer HeLa cells were examined using an MTT assay. Four compounds having a hydrophobic cinnamate side chain showed antiproliferative activity, which may be due to increased cell permeability.

Original languageEnglish
Pages (from-to)1883-1886
Number of pages4
JournalBioscience, Biotechnology and Biochemistry
Volume80
Issue number10
DOIs
Publication statusPublished - 2016

Fingerprint

Cinnamates
Taxus
Taxoids
Diterpenes
HeLa Cells
Uterine Cervical Neoplasms
Permeability
Assays
Cells
taxane

Keywords

  • Antiproliferative activity
  • Apoptosis
  • HeLa cells
  • Taxanes
  • Taxus chinensis var. Mairei

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biotechnology
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

Cite this

Inhibitory effect of 13 taxane diterpenoids from Chinese yew (Taxus chinensis var. mairei) on the proliferation of hela cervical cancer cells. / Liu, Hai Sheng; Gao, Yu Huan; Liu, Li Hong; Liu, Wei; Shi, Qing Wen; Dong, Mei; Suzuki, Toshikazu; Kiyota, Hiromasa.

In: Bioscience, Biotechnology and Biochemistry, Vol. 80, No. 10, 2016, p. 1883-1886.

Research output: Contribution to journalArticle

Liu, Hai Sheng ; Gao, Yu Huan ; Liu, Li Hong ; Liu, Wei ; Shi, Qing Wen ; Dong, Mei ; Suzuki, Toshikazu ; Kiyota, Hiromasa. / Inhibitory effect of 13 taxane diterpenoids from Chinese yew (Taxus chinensis var. mairei) on the proliferation of hela cervical cancer cells. In: Bioscience, Biotechnology and Biochemistry. 2016 ; Vol. 80, No. 10. pp. 1883-1886.
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