Inhibitory effect of 13 taxane diterpenoids from Chinese yew (Taxus chinensis var. mairei) on the proliferation of hela cervical cancer cells

Hai Sheng Liu; Yu Huan Gao; Li Hong Liu; Wei Liu; Qing Wen Shi; Mei Dong; Toshikazu Suzuki; Hiromasa Kiyota

doi:10.1080/09168451.2016.1194182

Inhibitory effect of 13 taxane diterpenoids from Chinese yew (Taxus chinensis var. mairei) on the proliferation of hela cervical cancer cells

Hai Sheng Liu, Yu Huan Gao, Li Hong Liu, Wei Liu, Qing Wen Shi, Mei Dong, Toshikazu Suzuki, Hiromasa Kiyota

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

The inhibitory effect of 13 taxanes isolated from the Chinese yew (Taxus chinensis var. mairei) on the proliferation of human cervical cancer HeLa cells were examined using an MTT assay. Four compounds having a hydrophobic cinnamate side chain showed antiproliferative activity, which may be due to increased cell permeability.

Original language	English
Pages (from-to)	1883-1886
Number of pages	4
Journal	Bioscience, Biotechnology and Biochemistry
Volume	80
Issue number	10
DOIs	https://doi.org/10.1080/09168451.2016.1194182
Publication status	Published - 2016

Keywords

Antiproliferative activity
Apoptosis
HeLa cells
Taxanes
Taxus chinensis var. Mairei

ASJC Scopus subject areas

Biotechnology
Analytical Chemistry
Biochemistry
Applied Microbiology and Biotechnology
Molecular Biology
Organic Chemistry

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Inhibitory effect of 13 taxane diterpenoids from Chinese yew (Taxus chinensis var. mairei) on the proliferation of hela cervical cancer cells. / Liu, Hai Sheng; Gao, Yu Huan; Liu, Li Hong; Liu, Wei; Shi, Qing Wen; Dong, Mei; Suzuki, Toshikazu; Kiyota, Hiromasa.

In: Bioscience, Biotechnology and Biochemistry, Vol. 80, No. 10, 2016, p. 1883-1886.

Research output: Contribution to journal › Article › peer-review

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