Inhibitory effect of 13 taxane diterpenoids from Chinese yew (Taxus chinensis var. mairei) on the proliferation of hela cervical cancer cells

Hai Sheng Liu; Yu Huan Gao; Li Hong Liu; Wei Liu; Qing Wen Shi; Mei Dong; Toshikazu Suzuki; Hiromasa Kiyota

doi:10.1080/09168451.2016.1194182

Inhibitory effect of 13 taxane diterpenoids from Chinese yew (Taxus chinensis var. mairei) on the proliferation of hela cervical cancer cells

Hai Sheng Liu, Yu Huan Gao, Li Hong Liu, Wei Liu, Qing Wen Shi, Mei Dong, Toshikazu Suzuki, Hiromasa Kiyota

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

The inhibitory effect of 13 taxanes isolated from the Chinese yew (Taxus chinensis var. mairei) on the proliferation of human cervical cancer HeLa cells were examined using an MTT assay. Four compounds having a hydrophobic cinnamate side chain showed antiproliferative activity, which may be due to increased cell permeability.

Original language	English
Pages (from-to)	1883-1886
Number of pages	4
Journal	Bioscience, Biotechnology and Biochemistry
Volume	80
Issue number	10
DOIs	https://doi.org/10.1080/09168451.2016.1194182
Publication status	Published - 2016

Keywords

Antiproliferative activity
Apoptosis
HeLa cells
Taxanes
Taxus chinensis var. Mairei

ASJC Scopus subject areas

Biotechnology
Analytical Chemistry
Biochemistry
Applied Microbiology and Biotechnology
Molecular Biology
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/09168451.2016.1194182

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title = "Inhibitory effect of 13 taxane diterpenoids from Chinese yew (Taxus chinensis var. mairei) on the proliferation of hela cervical cancer cells",

abstract = "The inhibitory effect of 13 taxanes isolated from the Chinese yew (Taxus chinensis var. mairei) on the proliferation of human cervical cancer HeLa cells were examined using an MTT assay. Four compounds having a hydrophobic cinnamate side chain showed antiproliferative activity, which may be due to increased cell permeability.",

keywords = "Antiproliferative activity, Apoptosis, HeLa cells, Taxanes, Taxus chinensis var. Mairei",

author = "Liu, {Hai Sheng} and Gao, {Yu Huan} and Liu, {Li Hong} and Wei Liu and Shi, {Qing Wen} and Mei Dong and Toshikazu Suzuki and Hiromasa Kiyota",

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doi = "10.1080/09168451.2016.1194182",

language = "English",

volume = "80",

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AU - Liu, Hai Sheng

AU - Gao, Yu Huan

AU - Liu, Li Hong

AU - Liu, Wei

AU - Shi, Qing Wen

AU - Dong, Mei

AU - Suzuki, Toshikazu

AU - Kiyota, Hiromasa

PY - 2016

Y1 - 2016

N2 - The inhibitory effect of 13 taxanes isolated from the Chinese yew (Taxus chinensis var. mairei) on the proliferation of human cervical cancer HeLa cells were examined using an MTT assay. Four compounds having a hydrophobic cinnamate side chain showed antiproliferative activity, which may be due to increased cell permeability.

AB - The inhibitory effect of 13 taxanes isolated from the Chinese yew (Taxus chinensis var. mairei) on the proliferation of human cervical cancer HeLa cells were examined using an MTT assay. Four compounds having a hydrophobic cinnamate side chain showed antiproliferative activity, which may be due to increased cell permeability.

KW - Antiproliferative activity

KW - Apoptosis

KW - HeLa cells

KW - Taxanes

KW - Taxus chinensis var. Mairei

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ER -

Inhibitory effect of 13 taxane diterpenoids from Chinese yew (Taxus chinensis var. mairei) on the proliferation of hela cervical cancer cells

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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