Inhibitory activity of chlorophyllin on the genotoxicity of carcinogens in Drosophila

Tomoe Negishi, Hiromi Nakano, Ayumi Kitamura, Chiho Itome, Teruko Shiotani, Hikoya Hayatsu

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30 Citations (Scopus)

Abstract

Antimutagenic activity of copper chlorophyllin against various carcinogenic mutagens was assayed with Drosophila genotoxicity tests, i.e., the wing spot test for detecting somatic cell mutations and the DNA repair test for detecting DNA damage. In these tests, Drosophila larvae were fed carcinogens together with chlorophyllin. Polycyclic aromatic compounds, including heterocyclic amines, polycyclic aromatic hydrocarbons, aromatic amines and aromatic nitro compounds, were subject to inhibition, with a few exceptions. The results support the view that chlorophyllin traps carcinogens by forming complexes, thereby inhibiting the absorption of these compounds from the digestive tract. Consistent with this mechanism, Sepharose-supported chlorophyllin in the feed inhibited the Trp-P-2-induced wing spot formation, while Sepharose itself was ineffective.

Original languageEnglish
Pages (from-to)157-164
Number of pages8
JournalCancer Letters
Volume83
Issue number1-2
DOIs
Publication statusPublished - Aug 15 1994

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Keywords

  • Antigenotoxicity
  • Cu-chlorophyllin
  • Drosophila

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

Cite this

Negishi, T., Nakano, H., Kitamura, A., Itome, C., Shiotani, T., & Hayatsu, H. (1994). Inhibitory activity of chlorophyllin on the genotoxicity of carcinogens in Drosophila. Cancer Letters, 83(1-2), 157-164. https://doi.org/10.1016/0304-3835(94)90313-1