Inhibitor of growth (ING) family: An emerging molecular target for cancer therapy

Esra Gunduz, Mehmet Gunduz, Levent Bekir Beder, Ryo Tamamura, Hitoshi Nagatsuka, Noriyuki Nagai

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

ING1 gene, the founding member of the ING tumor suppressor family, was originally identified through subtractive hybridization between normal mammary epithelial cells and breast cancer cell lines, and subsequent in vivo selection of genetic suppressor element that displayed oncogenic features. Soon after identification of ING1, four additional members of the ING family (ING2-5) were cloned and all the gene products contain a highly conserved plant homeodomain (PHD) finger motif in the carboxy (C)-terminal end, that plays important role for their function. Furthermore, ING family members contain nuclear localization signals and N-terminal sequences important in the interaction with historie acetyltransferase (HAT) and histone deacetyltransferase (HDAC) that regulate gene promoter activity within chromatin. Although exact functions of ING family genes have not been clarified, the gene products are involved in transcriptional regulation, apoptosis, cell cyle, angiogenesis and DNA repair through p53-dependent and -independent pathways. Chromosomal deletion and decreased expression of each ING family member gene in various cancer types strongly suggested products of these genes as tumor suppressor factors. Rare mutation but frequent allelic loss and epigenetic changes have been shown in ING family genes, suggesting them as a class II tumor suppressor gene. This review summarizes the known biological functions of the ING tumor suppressors and signaling related pathways.

Original languageEnglish
Pages (from-to)1-10
Number of pages10
JournalJournal of Hard Tissue Biology
Volume17
Issue number1
DOIs
Publication statusPublished - 2008

Keywords

  • Cancer
  • Head and neck cancer
  • ING family
  • ING1
  • Tumor suppressor gene

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biochemistry
  • Biomaterials
  • Orthopedics and Sports Medicine
  • Dentistry(all)
  • Cell Biology

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