Inhibition of the mutagenic activities of the amino acid pyrolysis products by hemin and other biological pyrrole pigments was investigated using the Ames' Salmonella/microsome system. Hemin, biliverdin and chlorophyllin showed inhibition to all the six mutagens tested, and protoporphyrin to three of them. Hemin was the most effective among these pigments; e.g., the mutageniciti of 1.8 nmole Trp-P-1 (3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole) was suppressed to 50 % by 1-3 nmole of hemin. Hemin appears to interact with the metabolically activated form of Trp-P-1 and as a result to inhibit the mutagenicity.
|Number of pages||7|
|Journal||Biochemical and Biophysical Research Communications|
|Publication status||Published - Jan 29 1980|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology