Inhibition of multiplication of Mycobacterium leprae in mouse foot pads by recombinant Bacillus Catmette-Guerin (BCG)

Naoya Ohara, Masanori Matsuoka, Hiroko Nomaguchi, Mariko Naito, Takeshi Yamada

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Immunization of mice with recombinant Mycobacterium bovis Bacillus Calmette-Guerin (rBCG) which over-produces a putative protective antigen candidate, the A component of antigen 85 complex (Ag85A), reduced the multiplication of Mycobacterium leprae in the foot pads of mice. The inhibition by this rBCG (rBCG/85A) was more evident than that with parental BCG. Repeated rBCG/85A immunization significantly could reduce M. leplae multiplication in mice. This is first report of rBCG to control mycobacterial infection in animal model. Therefore, rBCG technique may be useful for the development of a more effective mycobacteria vaccine.

Original languageEnglish
Pages (from-to)1294-1297
Number of pages4
JournalVaccine
Volume18
Issue number14
DOIs
Publication statusPublished - Feb 4 2000
Externally publishedYes

Keywords

  • BCG
  • Leprosy
  • Vaccine

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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