Inhibition of multiplication of Mycobacterium leprae in mouse foot pads by immunization with ribosomal fraction and culture flitrate from Mycobacterium bovis BCG

Masanori Matsuoka, Hiroko Nomaguchi, Hideharu Yukitake, Naoya Ohara, Sohkichi Matsumoto, Katsutoshi Mise, Takeshi Yamada

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Immunization of mice with the ribosomal fraction from ruptured Mycobacterium bovis Bacillus Calmette-Guerin (BCG) and the culture filtrate reduced remarkably the multiplication of Mycobacterium leprae in the foot pads of mice. This is the first reported case of the protective activity against M. leprae multiplication in mice of the BCG ribosomal fraction and culture filtrate. The inhibition was more evident with the culture filtrate than with the ribosomal fraction. When the ribosomal proteins separated from ribosomal RNA were injected into mice, only slight inhibition was observed. Ribosomal RNA alone did not inhibit at all, in contrast to the conclusion reported by Youmans and Youmans.

Original languageEnglish
Pages (from-to)1214-1217
Number of pages4
JournalVaccine
Volume15
Issue number11
DOIs
Publication statusPublished - Aug 1 1997
Externally publishedYes

Keywords

  • BCG culture filtrate
  • BCG ribosomal vaccine
  • Leprosy vaccine

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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