Inhibition of human immunodeficiency virus type 1 Rev function by a Rev mutant which interferes with nuclear/nucleolar localization of Rev

Satoshi Kubota, Rika Furuta, Masatoshi Maki, Masakazu Hatanaka

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

A nonfunctional mutant of human immunodeficiency virus type 1 Rev was created by deleting seven amino acid residues within the nucleolar targeting signal. This mutant Rev remained in the cytoplasm in expressed cells and strongly inhibited the function of Rev by interfering with the nuclear/nucleolar localization of coexpressed Rev. These findings strongly suggest the multimerization of Rev in the cytoplasm before migration to the nucleus/nucleolus, where wild-type Rev functions as a trans-regulator.

Original languageEnglish
Pages (from-to)2510-2513
Number of pages4
JournalJournal of Virology
Volume66
Issue number4
Publication statusPublished - Apr 1992
Externally publishedYes

Fingerprint

Human immunodeficiency virus 1
HIV-1
Cytoplasm
cytoplasm
mutants
cell nucleolus
Amino Acids
amino acids
cells

ASJC Scopus subject areas

  • Immunology

Cite this

Inhibition of human immunodeficiency virus type 1 Rev function by a Rev mutant which interferes with nuclear/nucleolar localization of Rev. / Kubota, Satoshi; Furuta, Rika; Maki, Masatoshi; Hatanaka, Masakazu.

In: Journal of Virology, Vol. 66, No. 4, 04.1992, p. 2510-2513.

Research output: Contribution to journalArticle

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