Inhibition by (-)-Persenone A-related compounds of nitric oxide and superoxide generation from inflammatory leukocytes

Oe Kyung Kim, Akira Murakami, Yoshimasa Nakamura, Ha Won Kim, Hajime Ohigashi

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

We have previously reported that persenone A, isolated from avocado fruit, is an effective inhibitor of both nitric oxide (NO) and superoxide (O2) generation in cell culture systems. In this study, we have prepared four persenone A-related compounds and examined their inhibition of NO and O2 generation from inflammatory leukocytes. Some structural importance in persenone A to attenuate free radical generation is discussed.

Original languageEnglish
Pages (from-to)2500-2503
Number of pages4
JournalBioscience, Biotechnology and Biochemistry
Volume64
Issue number11
DOIs
Publication statusPublished - Jan 1 2000
Externally publishedYes

Keywords

  • Nitric oxide
  • Persenone A
  • Superoxide

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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