Inheritance and Developmental Pattern of Cerebral Hernia in the Crested Polish Chicken

Keiji Yoshimura, Keiji Kinoshita, Makoto Mizutani, Yoichi Matsuda, Noboru Saito

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A number of crested chicken strains, such as the Polish chicken, exhibit a bony protuberance in the anterodorsal region of their skulls. The shape of their brain shows the anatomical peculiarity that is characterized by the upthrusting of cerebral hemispheres, called "cerebral hernia." Some early works suggested that this phenotype may be caused by a genetic factor and any modifiers influencing the development of brain and/or skull. However, the causative gene and its formation mechanism are still unclear. The present study is aimed to analyze the inheritance and ontogenic process of cerebral hernia in the crested Polish chicken. Firstly, we constructed the resource family with the Polish chicken and PNP inbred strain. Genetic analysis of this family revealed that cerebral hernia is controlled by a single autosomal recessive gene and is closely associated with crest formation. Furthermore, our morphological analysis of brain structures in the progenies suggested that the significant enlargement of brain cavity at later stages of embryos, particularly after 15 days of incubation, may be the main cause of cerebral hernia.

Original languageEnglish
Pages (from-to)613-620
Number of pages8
JournalJournal of Experimental Zoology Part B: Molecular and Developmental Evolution
Volume318
Issue number8
DOIs
Publication statusPublished - Dec 2012
Externally publishedYes

Fingerprint

Encephalocele
Inheritance Patterns
hernia
brain
Chickens
inheritance (genetics)
chickens
Brain
skull
Skull
Recessive Genes
modifiers (genes)
gene
recessive genes
Cerebrum
genetic analysis
formation mechanism
genetic techniques and protocols
phenotype
embryo

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Ecology, Evolution, Behavior and Systematics
  • Molecular Medicine
  • Genetics
  • Developmental Biology

Cite this

Inheritance and Developmental Pattern of Cerebral Hernia in the Crested Polish Chicken. / Yoshimura, Keiji; Kinoshita, Keiji; Mizutani, Makoto; Matsuda, Yoichi; Saito, Noboru.

In: Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, Vol. 318, No. 8, 12.2012, p. 613-620.

Research output: Contribution to journalArticle

Yoshimura, Keiji ; Kinoshita, Keiji ; Mizutani, Makoto ; Matsuda, Yoichi ; Saito, Noboru. / Inheritance and Developmental Pattern of Cerebral Hernia in the Crested Polish Chicken. In: Journal of Experimental Zoology Part B: Molecular and Developmental Evolution. 2012 ; Vol. 318, No. 8. pp. 613-620.
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