Infusion of hypertonic saline into the lung parenchyma during radiofrequency ablation of the lungs with multitined expandable electrodes: Results using a porcine model

Tatsuhiko Iishi, Takao Hiraki, Hidefumi Mimura, Hideo Gobara, Taichi Kurose, Hiroyasu Fujiwara, Jun Sakurai, Hiroyuki Yanai, Tadashi Yoshino, Susumu Kanazawa

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The present study was performed to clarify the effect of hypertonic saline infusion into the lung parenchyma on radiofrequency ablation (RFA) of the lungs. A total of 20 ablation zones were created in 3 pigs. The ablation zones were divided into 3 groups. Group 1 (n = 6) consisted of ablation zones created by applying smaller radiofrequency (RF) power without saline infusion; group 2 (n = 5) zones were created by applying greater RF power without saline infusion; and group 3 (n = 9) zones were created by applying greater RF power with saline infusion. The techniques of saline infusion included administration of hypertonic saline 1 ml before RFA, followed by continuous administration at a rate of lml/min during the first 2min after the initiation of RFA. The ablation parameters and coagulation necrosis volumes were compared among the groups. Group 3 had a tendency toward smaller mean impedance than group 1 (p = 0.059) and group 2 (p = 0.053). Group 3 showed significantly longer RF application time than group 2 (p - 0.004) and significantly greater maximum RF power than group 1 (p = 0.001) and group 2 (p = 0.004). Group 3 showed significantly larger coagulation necrosis volume (mean, 1,421mm3) than group 2 (mean, 858 mm3, p = 0.039) and had a tendency toward larger necrosis volume than group 1 (mean, 878 mm3, p = 0.077). Although this small study had limited statistical power, hypertonic saline infusion during RFA appeared to enlarge coagulation necrosis of the lung parenchyma.

Original languageEnglish
Pages (from-to)137-144
Number of pages8
JournalActa medica Okayama
Volume63
Issue number3
Publication statusPublished - Jul 2009

Keywords

  • Experimental study
  • Lung
  • Radiofrequency ablation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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