Influence of viral load and genotype in the progression of hepatitis B-associated liver cirrhosis to hepatocellular carcinoma

Sabina Mahmood, Gouichi Niiyama, Ayumi Kamei, Akiyoshi Izumi, Keiichi Nakata, Hideji Ikeda, Mitsuhiko Suehiro, Miwa Kawanaka, Kazumi Togawa, Gotaro Yamada

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50 Citations (Scopus)

Abstract

Aim/Background: Hepatitis B virus (HBV) is an important factor in the development of hepatocellular carcinoma (HCC). We studied the influence of HBV viral load on HCC occurrence in HBV related liver cirrhosis (LC). Patients and Methods: Ninety-one LC patients were followed up over a period of 7 years. Twenty three patients received Interferon (IFN) therapy. Results: In 7 years, 23 patients developed HCC. Of them twenty-two (95.6%) were of genotype C. HBV DNA was found to be the only significant variable associated with HCC occurrence on both univariate (P = 0.029) and multivariate analysis (odds ratio 2.33; P<0.033). The cumulative survival at 5 years was 83% and the annual rate of hepatitis B surface antigen clearance was 0.9 %. All of 17 HCC patients observed over a period of 5 years or more belonged to the continuously high HBV DNA group (annual average > 3.7 log copies/ml) and all but one belonged to the continuously high alanine aminotransferase group (annual average > 40 IU/1). Conclusion: Patients with genotype C and a continuously high HBV DNA for 5 years or more are at a high-risk group for HCC development. Maintaining continuously low HBV DNA for 3 years or more with anti-viral therapy, may be useful in preventing or delaying HCC occurrence.

Original languageEnglish
Pages (from-to)220-225
Number of pages6
JournalLiver International
Volume25
Issue number2
DOIs
Publication statusPublished - Apr 1 2005
Externally publishedYes

Keywords

  • Genotype
  • Hepatitis B viral load
  • Hepatocellular carcinoma
  • Liver cirrhosis

ASJC Scopus subject areas

  • Hepatology

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    Mahmood, S., Niiyama, G., Kamei, A., Izumi, A., Nakata, K., Ikeda, H., Suehiro, M., Kawanaka, M., Togawa, K., & Yamada, G. (2005). Influence of viral load and genotype in the progression of hepatitis B-associated liver cirrhosis to hepatocellular carcinoma. Liver International, 25(2), 220-225. https://doi.org/10.1111/j.1478-3231.2005.01077.x