Influence of vestibulo-sympathetic reflex on muscle sympathetic outflow during head-down tilt.

J. Kawanokuchi, Q. Fu, J. Cui, Y. Niimi, Atsunori Kamiya, D. Michikami, S. Iwase, T. Mano, A. Suzumura

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

To clarify the response of muscle sympathetic nerve activity (MSNA) to static stimulation of otolith organs in a craniocaudal direction (+Gz) in humans, we examined the effect of otolith stimulation on MSNA without changing the effect of cardiopulmonary baroreceptors using a 6-8.5 degrees head-down tilt (HDT) and lower body negative pressure (LBNP) device. Before the study, we established that 6-8.5 degrees HDT with 10 mmHg LBNP caused a fluid shift to the degree that the thoracic impedance was the same as the supine position without LBNP. Subjects were young male volunteers aged 22.1 +/- 3.8 years who gave informed consent. MSNA was recorded from the tibial nerve by microneurography simultaneously with heart rate (ECG), thoracic fluid volume (impedance method), and blood pressure (tonometric method). During 6-8.5 degrees HDT with 10 mmHg LBNP, MSNA was suppressed slightly without significantly changing heart rate, thoracic impedance, or mean arterial blood pressure. The results suggest that the sympathosuppression was related not to the result of cardiopulmonary [correction of cardioplumonary] loading but to the -Gz change (caudocranial direction [correction of dirction]) of 0.1 G. It is estimated that the vestibulo-sympathetic reflex may suppress sympathetic outflow to muscles in humans.

Original languageEnglish
Pages (from-to)66-68
Number of pages3
JournalEnvironmental medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University
Volume45
Issue number2
Publication statusPublished - Jan 1 2001
Externally publishedYes

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Head-Down Tilt
Lower Body Negative Pressure
Reflex
Muscles
Electric Impedance
Otolithic Membrane
Thorax
Arterial Pressure
Heart Rate
Fluid Shifts
Tibial Nerve
Pressoreceptors
Supine Position
Informed Consent
Volunteers
Electrocardiography
Blood Pressure
Equipment and Supplies

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Influence of vestibulo-sympathetic reflex on muscle sympathetic outflow during head-down tilt. / Kawanokuchi, J.; Fu, Q.; Cui, J.; Niimi, Y.; Kamiya, Atsunori; Michikami, D.; Iwase, S.; Mano, T.; Suzumura, A.

In: Environmental medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University, Vol. 45, No. 2, 01.01.2001, p. 66-68.

Research output: Contribution to journalArticle

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