Abstract

Purpose The purpose of this study was to evaluate altered pulmonary function retrospectively after RFA. Methods This retrospective study comprised 41 ablation sessions for 39 patients (22 men and 17 women; mean age, 64.8 years). Vital capacity (VC) and forced expiratory volume in 1 s (FEV 1) at 1 and 3 months after RFA were compared with the baseline (i.e., values before RFA). To evaluate the factors that influenced impaired pulmonary function, univariate analysis was performed by using multiple variables. If two or more variables were indicated as statistically significant by univariate analysis, these variables were subjected to multivariate analysis to identify independent factors. Results The mean VC and FEV1 before RFA and 1 and 3 months after RFA were 3.04 and 2.24 l, 2.79 and 2.11 l, and 2.85 and 2.13 l, respectively. The values at 1 and 3 months were significantly lower than the baseline. Severe pleuritis after RFA was identified as the independent factor influencing impaired VC at 1 month (P = 0.003). For impaired FEV1 at 1 month, only severe pleuritis (P = 0.01) was statistically significant by univariate analysis. At 3 months, severe pleuritis (VC, P = 0.019; FEV1, P = 0.003) and an ablated parenchymal volume C≥20 cm3 (VC, P = 0.047; FEV1, P = 0.038) were independent factors for impaired VC and FEV1. Conclusions Pulmonary function decreased after RFA. RFA-induced severe pleuritis and ablation of a large volume of marginal parenchyma were associated with impaired pulmonary function.

Original languageEnglish
Pages (from-to)860-867
Number of pages8
JournalCardioVascular and Interventional Radiology
Volume35
Issue number4
DOIs
Publication statusPublished - Aug 2012

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Vital Capacity
Lung Neoplasms
Pleurisy
Lung
Forced Expiratory Volume
Multivariate Analysis
Retrospective Studies

Keywords

  • Lung
  • Pulmonary function
  • Radiofrequency ablation

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

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title = "Influence of radiofrequency ablation of lung cancer on pulmonary function",
abstract = "Purpose The purpose of this study was to evaluate altered pulmonary function retrospectively after RFA. Methods This retrospective study comprised 41 ablation sessions for 39 patients (22 men and 17 women; mean age, 64.8 years). Vital capacity (VC) and forced expiratory volume in 1 s (FEV 1) at 1 and 3 months after RFA were compared with the baseline (i.e., values before RFA). To evaluate the factors that influenced impaired pulmonary function, univariate analysis was performed by using multiple variables. If two or more variables were indicated as statistically significant by univariate analysis, these variables were subjected to multivariate analysis to identify independent factors. Results The mean VC and FEV1 before RFA and 1 and 3 months after RFA were 3.04 and 2.24 l, 2.79 and 2.11 l, and 2.85 and 2.13 l, respectively. The values at 1 and 3 months were significantly lower than the baseline. Severe pleuritis after RFA was identified as the independent factor influencing impaired VC at 1 month (P = 0.003). For impaired FEV1 at 1 month, only severe pleuritis (P = 0.01) was statistically significant by univariate analysis. At 3 months, severe pleuritis (VC, P = 0.019; FEV1, P = 0.003) and an ablated parenchymal volume C≥20 cm3 (VC, P = 0.047; FEV1, P = 0.038) were independent factors for impaired VC and FEV1. Conclusions Pulmonary function decreased after RFA. RFA-induced severe pleuritis and ablation of a large volume of marginal parenchyma were associated with impaired pulmonary function.",
keywords = "Lung, Pulmonary function, Radiofrequency ablation",
author = "Akihiro Tada and Takao Hiraki and Toshihiro Iguchi and Hideo Gobara and Hidefumi Mimura and Shinichi Toyooka and Katsuyuki Kiura and Toshihide Tsuda and Toshiharu Mitsuhashi and Susumu Kanazawa",
year = "2012",
month = "8",
doi = "10.1007/s00270-011-0221-z",
language = "English",
volume = "35",
pages = "860--867",
journal = "CardioVascular and Interventional Radiology",
issn = "7415-5101",
publisher = "Springer Verlag",
number = "4",

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TY - JOUR

T1 - Influence of radiofrequency ablation of lung cancer on pulmonary function

AU - Tada, Akihiro

AU - Hiraki, Takao

AU - Iguchi, Toshihiro

AU - Gobara, Hideo

AU - Mimura, Hidefumi

AU - Toyooka, Shinichi

AU - Kiura, Katsuyuki

AU - Tsuda, Toshihide

AU - Mitsuhashi, Toshiharu

AU - Kanazawa, Susumu

PY - 2012/8

Y1 - 2012/8

N2 - Purpose The purpose of this study was to evaluate altered pulmonary function retrospectively after RFA. Methods This retrospective study comprised 41 ablation sessions for 39 patients (22 men and 17 women; mean age, 64.8 years). Vital capacity (VC) and forced expiratory volume in 1 s (FEV 1) at 1 and 3 months after RFA were compared with the baseline (i.e., values before RFA). To evaluate the factors that influenced impaired pulmonary function, univariate analysis was performed by using multiple variables. If two or more variables were indicated as statistically significant by univariate analysis, these variables were subjected to multivariate analysis to identify independent factors. Results The mean VC and FEV1 before RFA and 1 and 3 months after RFA were 3.04 and 2.24 l, 2.79 and 2.11 l, and 2.85 and 2.13 l, respectively. The values at 1 and 3 months were significantly lower than the baseline. Severe pleuritis after RFA was identified as the independent factor influencing impaired VC at 1 month (P = 0.003). For impaired FEV1 at 1 month, only severe pleuritis (P = 0.01) was statistically significant by univariate analysis. At 3 months, severe pleuritis (VC, P = 0.019; FEV1, P = 0.003) and an ablated parenchymal volume C≥20 cm3 (VC, P = 0.047; FEV1, P = 0.038) were independent factors for impaired VC and FEV1. Conclusions Pulmonary function decreased after RFA. RFA-induced severe pleuritis and ablation of a large volume of marginal parenchyma were associated with impaired pulmonary function.

AB - Purpose The purpose of this study was to evaluate altered pulmonary function retrospectively after RFA. Methods This retrospective study comprised 41 ablation sessions for 39 patients (22 men and 17 women; mean age, 64.8 years). Vital capacity (VC) and forced expiratory volume in 1 s (FEV 1) at 1 and 3 months after RFA were compared with the baseline (i.e., values before RFA). To evaluate the factors that influenced impaired pulmonary function, univariate analysis was performed by using multiple variables. If two or more variables were indicated as statistically significant by univariate analysis, these variables were subjected to multivariate analysis to identify independent factors. Results The mean VC and FEV1 before RFA and 1 and 3 months after RFA were 3.04 and 2.24 l, 2.79 and 2.11 l, and 2.85 and 2.13 l, respectively. The values at 1 and 3 months were significantly lower than the baseline. Severe pleuritis after RFA was identified as the independent factor influencing impaired VC at 1 month (P = 0.003). For impaired FEV1 at 1 month, only severe pleuritis (P = 0.01) was statistically significant by univariate analysis. At 3 months, severe pleuritis (VC, P = 0.019; FEV1, P = 0.003) and an ablated parenchymal volume C≥20 cm3 (VC, P = 0.047; FEV1, P = 0.038) were independent factors for impaired VC and FEV1. Conclusions Pulmonary function decreased after RFA. RFA-induced severe pleuritis and ablation of a large volume of marginal parenchyma were associated with impaired pulmonary function.

KW - Lung

KW - Pulmonary function

KW - Radiofrequency ablation

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U2 - 10.1007/s00270-011-0221-z

DO - 10.1007/s00270-011-0221-z

M3 - Article

C2 - 21725672

AN - SCOPUS:84866618723

VL - 35

SP - 860

EP - 867

JO - CardioVascular and Interventional Radiology

JF - CardioVascular and Interventional Radiology

SN - 7415-5101

IS - 4

ER -