Abstract
Skin permeation of amino acids through excised rat skin was measured at various pH values. The permeabilities varied with the donor pH and amino acid, indicating that each ionic species of amino acid may have a different permeability. The permeability coefficient of each ion was estimated from the permeability-pH profiles using the dissociation constants. The estimated values for mono-cation and uncharged zwitterion were not dependent on the lipophilicity but on the size of the amino acid, suggesting a porous mechanism of transport. The permeability coefficient was highest for di-cation, followed by mono-cation, positively charged, uncharged and negatively charged zwitterions. The electrical potential difference across the skin was too small to affect the permeation of ions. The permselective property of skin thus seems to be determined by the difference of diffusivity in aqueous pores of skin due to the hydration of ions and other factors.
| Original language | English |
|---|---|
| Pages (from-to) | 675-679 |
| Number of pages | 5 |
| Journal | Journal of Pharmacy and Pharmacology |
| Volume | 48 |
| Issue number | 7 |
| Publication status | Published - Jul 1996 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Pharmacology
- Pharmaceutical Science
Cite this
Influence of pH on skin permeation of amino acids. / Hatanaka, Tomomi; Kamon, Toshihiko; Uozumi, Chisato; Morigaki, Setsuko; Aiba, Tetsuya; Katayama, Kazunori; Koizumi, Tamotsu.
In: Journal of Pharmacy and Pharmacology, Vol. 48, No. 7, 07.1996, p. 675-679.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Influence of pH on skin permeation of amino acids
AU - Hatanaka, Tomomi
AU - Kamon, Toshihiko
AU - Uozumi, Chisato
AU - Morigaki, Setsuko
AU - Aiba, Tetsuya
AU - Katayama, Kazunori
AU - Koizumi, Tamotsu
PY - 1996/7
Y1 - 1996/7
N2 - Skin permeation of amino acids through excised rat skin was measured at various pH values. The permeabilities varied with the donor pH and amino acid, indicating that each ionic species of amino acid may have a different permeability. The permeability coefficient of each ion was estimated from the permeability-pH profiles using the dissociation constants. The estimated values for mono-cation and uncharged zwitterion were not dependent on the lipophilicity but on the size of the amino acid, suggesting a porous mechanism of transport. The permeability coefficient was highest for di-cation, followed by mono-cation, positively charged, uncharged and negatively charged zwitterions. The electrical potential difference across the skin was too small to affect the permeation of ions. The permselective property of skin thus seems to be determined by the difference of diffusivity in aqueous pores of skin due to the hydration of ions and other factors.
AB - Skin permeation of amino acids through excised rat skin was measured at various pH values. The permeabilities varied with the donor pH and amino acid, indicating that each ionic species of amino acid may have a different permeability. The permeability coefficient of each ion was estimated from the permeability-pH profiles using the dissociation constants. The estimated values for mono-cation and uncharged zwitterion were not dependent on the lipophilicity but on the size of the amino acid, suggesting a porous mechanism of transport. The permeability coefficient was highest for di-cation, followed by mono-cation, positively charged, uncharged and negatively charged zwitterions. The electrical potential difference across the skin was too small to affect the permeation of ions. The permselective property of skin thus seems to be determined by the difference of diffusivity in aqueous pores of skin due to the hydration of ions and other factors.
UR - http://www.scopus.com/inward/record.url?scp=0029810087&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029810087&partnerID=8YFLogxK
M3 - Article
VL - 48
SP - 675
EP - 679
JO - Journal of Pharmacy and Pharmacology
JF - Journal of Pharmacy and Pharmacology
SN - 0022-3573
IS - 7
ER -