Influence of oral adsorbent AST-120 on anticonvulsive effect of zonisamide in rats

Tomoko Toyota, Yoshihisa Kitamura, Hiroaki Araki, Noriaki Sadakane, Koujiro Futagami, Katsushi Furuno, Yutaka Gomita

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The influence of oral adsorbent AST-120 (Kremezin) on the anticonvulsive effect and pharmacokinetics of zonisamide was investigated. Oral administration of zonisamide (50 mg/kg) blocked the appearance of the tonic extension induced by maximal electroshock seizure. This effect of zonisamide was inhibited by the oral coadministration of AST-120 (5 g/kg). In pharmacokinetics study, the serum zonisamide concentration after coadministration of zonisamide and AST-120 was significantly lower than that of single administration of zonisamide. However, the anticonvulsive effect of zonisamide was not affected by the administration of AST-120 1.5 h after zonisamide administration. In this condition, the serum zonisamide concentration was not changed. In the in vitro study, AST-120 completely adsorbed zonisamide. These findings suggest that when AST-120 is administered concurrently with zonisamide, a significant inhibition of the anticonvulsive effect of zonisamide occurs, and the decrease in serum zonisamide concentration by the adsorption effect of AST-120 is related to this phenomenon.

Original languageEnglish
Pages (from-to)375-379
Number of pages5
JournalPharmacology Biochemistry and Behavior
Volume70
Issue number2-3
DOIs
Publication statusPublished - Nov 21 2001

Keywords

  • AST-120
  • Adsorption
  • Anticonvulsive effect
  • Blood concentration
  • Zonisamide

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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