Influence of oral adsorbent AST-120 on anticonvulsive effect of zonisamide in rats

Tomoko Toyota, Yoshihisa Kitamura, Hiroaki Araki, Noriaki Sadakane, Koujiro Futagami, Katsushi Furuno, Yutaka Gomita

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The influence of oral adsorbent AST-120 (Kremezin) on the anticonvulsive effect and pharmacokinetics of zonisamide was investigated. Oral administration of zonisamide (50 mg/kg) blocked the appearance of the tonic extension induced by maximal electroshock seizure. This effect of zonisamide was inhibited by the oral coadministration of AST-120 (5 g/kg). In pharmacokinetics study, the serum zonisamide concentration after coadministration of zonisamide and AST-120 was significantly lower than that of single administration of zonisamide. However, the anticonvulsive effect of zonisamide was not affected by the administration of AST-120 1.5 h after zonisamide administration. In this condition, the serum zonisamide concentration was not changed. In the in vitro study, AST-120 completely adsorbed zonisamide. These findings suggest that when AST-120 is administered concurrently with zonisamide, a significant inhibition of the anticonvulsive effect of zonisamide occurs, and the decrease in serum zonisamide concentration by the adsorption effect of AST-120 is related to this phenomenon.

Original languageEnglish
Pages (from-to)375-379
Number of pages5
JournalPharmacology Biochemistry and Behavior
Volume70
Issue number2-3
DOIs
Publication statusPublished - 2001

Fingerprint

zonisamide
Adsorbents
Rats
Pharmacokinetics
AST 120

Keywords

  • Adsorption
  • Anticonvulsive effect
  • AST-120
  • Blood concentration
  • Zonisamide

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

Cite this

Influence of oral adsorbent AST-120 on anticonvulsive effect of zonisamide in rats. / Toyota, Tomoko; Kitamura, Yoshihisa; Araki, Hiroaki; Sadakane, Noriaki; Futagami, Koujiro; Furuno, Katsushi; Gomita, Yutaka.

In: Pharmacology Biochemistry and Behavior, Vol. 70, No. 2-3, 2001, p. 375-379.

Research output: Contribution to journalArticle

Toyota, Tomoko ; Kitamura, Yoshihisa ; Araki, Hiroaki ; Sadakane, Noriaki ; Futagami, Koujiro ; Furuno, Katsushi ; Gomita, Yutaka. / Influence of oral adsorbent AST-120 on anticonvulsive effect of zonisamide in rats. In: Pharmacology Biochemistry and Behavior. 2001 ; Vol. 70, No. 2-3. pp. 375-379.
@article{b66cb9c5da3a41eb8b7ac850d6ca6672,
title = "Influence of oral adsorbent AST-120 on anticonvulsive effect of zonisamide in rats",
abstract = "The influence of oral adsorbent AST-120 (Kremezin) on the anticonvulsive effect and pharmacokinetics of zonisamide was investigated. Oral administration of zonisamide (50 mg/kg) blocked the appearance of the tonic extension induced by maximal electroshock seizure. This effect of zonisamide was inhibited by the oral coadministration of AST-120 (5 g/kg). In pharmacokinetics study, the serum zonisamide concentration after coadministration of zonisamide and AST-120 was significantly lower than that of single administration of zonisamide. However, the anticonvulsive effect of zonisamide was not affected by the administration of AST-120 1.5 h after zonisamide administration. In this condition, the serum zonisamide concentration was not changed. In the in vitro study, AST-120 completely adsorbed zonisamide. These findings suggest that when AST-120 is administered concurrently with zonisamide, a significant inhibition of the anticonvulsive effect of zonisamide occurs, and the decrease in serum zonisamide concentration by the adsorption effect of AST-120 is related to this phenomenon.",
keywords = "Adsorption, Anticonvulsive effect, AST-120, Blood concentration, Zonisamide",
author = "Tomoko Toyota and Yoshihisa Kitamura and Hiroaki Araki and Noriaki Sadakane and Koujiro Futagami and Katsushi Furuno and Yutaka Gomita",
year = "2001",
doi = "10.1016/S0091-3057(01)00617-7",
language = "English",
volume = "70",
pages = "375--379",
journal = "Pharmacology, Biochemistry and Behavior",
issn = "0091-3057",
publisher = "Elsevier Inc.",
number = "2-3",

}

TY - JOUR

T1 - Influence of oral adsorbent AST-120 on anticonvulsive effect of zonisamide in rats

AU - Toyota, Tomoko

AU - Kitamura, Yoshihisa

AU - Araki, Hiroaki

AU - Sadakane, Noriaki

AU - Futagami, Koujiro

AU - Furuno, Katsushi

AU - Gomita, Yutaka

PY - 2001

Y1 - 2001

N2 - The influence of oral adsorbent AST-120 (Kremezin) on the anticonvulsive effect and pharmacokinetics of zonisamide was investigated. Oral administration of zonisamide (50 mg/kg) blocked the appearance of the tonic extension induced by maximal electroshock seizure. This effect of zonisamide was inhibited by the oral coadministration of AST-120 (5 g/kg). In pharmacokinetics study, the serum zonisamide concentration after coadministration of zonisamide and AST-120 was significantly lower than that of single administration of zonisamide. However, the anticonvulsive effect of zonisamide was not affected by the administration of AST-120 1.5 h after zonisamide administration. In this condition, the serum zonisamide concentration was not changed. In the in vitro study, AST-120 completely adsorbed zonisamide. These findings suggest that when AST-120 is administered concurrently with zonisamide, a significant inhibition of the anticonvulsive effect of zonisamide occurs, and the decrease in serum zonisamide concentration by the adsorption effect of AST-120 is related to this phenomenon.

AB - The influence of oral adsorbent AST-120 (Kremezin) on the anticonvulsive effect and pharmacokinetics of zonisamide was investigated. Oral administration of zonisamide (50 mg/kg) blocked the appearance of the tonic extension induced by maximal electroshock seizure. This effect of zonisamide was inhibited by the oral coadministration of AST-120 (5 g/kg). In pharmacokinetics study, the serum zonisamide concentration after coadministration of zonisamide and AST-120 was significantly lower than that of single administration of zonisamide. However, the anticonvulsive effect of zonisamide was not affected by the administration of AST-120 1.5 h after zonisamide administration. In this condition, the serum zonisamide concentration was not changed. In the in vitro study, AST-120 completely adsorbed zonisamide. These findings suggest that when AST-120 is administered concurrently with zonisamide, a significant inhibition of the anticonvulsive effect of zonisamide occurs, and the decrease in serum zonisamide concentration by the adsorption effect of AST-120 is related to this phenomenon.

KW - Adsorption

KW - Anticonvulsive effect

KW - AST-120

KW - Blood concentration

KW - Zonisamide

UR - http://www.scopus.com/inward/record.url?scp=0035163835&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035163835&partnerID=8YFLogxK

U2 - 10.1016/S0091-3057(01)00617-7

DO - 10.1016/S0091-3057(01)00617-7

M3 - Article

C2 - 11701210

AN - SCOPUS:0035163835

VL - 70

SP - 375

EP - 379

JO - Pharmacology, Biochemistry and Behavior

JF - Pharmacology, Biochemistry and Behavior

SN - 0091-3057

IS - 2-3

ER -