Influence of multi-leaf collimator leaf transmission on head and neck intensity-modulated radiation therapy and volumetric-modulated arc therapy planning

Motoharu Sasaki, Masahide Tominaga, Takeshi Kamomae, Hitoshi Ikushima, Motonori Kitaoka, Ryota Bando, Kanako Sakuragawa, Masataka Oita

Research output: Contribution to journalArticle


The aim of this study was to quantify the effect of multi-leaf collimators (MLCs) with different leaf widths on the planning of intensity-modulated radiation therapy (IMRT) and volumetric-modulated arc therapy (VMAT). Toward this objective, dose transmission through a high-definition 120-leaf MLC (HD120MLC) and 120-leaf Millennium MLC (M120MLC) was investigated, using it with a test case and clinical case studies. In test case, studies with IMRT and VMAT plans, the difference in MLC leaf width had a limited effect on planning target volumes (PTVs). Organs at risk (OARs) were more affected by a reduction in dose transmission through the MLC than by a reduction in MLC leaf width. The results of the test case studies and clinical case studies were mostly similar. In the latter, the different MLCs had no effect on the PTV regardless of the treatment method; however, the HD120MLC plans achieved dose reductions to OARs similar to or larger than the dose reduction of the M120MLC plans. The similar results of the test case and clinical case studies showed that despite a limitation of the irradiation field size, the HD120MLC plans were superior.

Original languageEnglish
Pages (from-to)511-525
Number of pages15
JournalJapanese Journal of Radiology
Issue number9
Publication statusPublished - Sep 1 2017



  • Head and neck cancer
  • Intensity-modulated radiation therapy
  • Multi-leaf collimator
  • Volumetric-modulated arc therapy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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