Abstract
We have investigated the effect of methylprednisolone on the intracellular activity of erythromycin and clindamycin in vitro. An assay system was developed for the determination of intracellular activity of antibiotics against Legionella pneumophila using guinea pig resident alveolar macrophages. Erythromycin at a concentration of 0.625 mg/L (5 x MIC) and clindamycin at a concentration of 8 mg/L (MIC) inhibited the growth of a single strain of L. pneumophila in macrophages, whilst ceftizoxime at a concentration of 0.625 mg/L (5 x MIC) did not. Methylprednisolone at therapeutic concentrations did not affect the intracellular antibacterial activity of either erythromycin or clindamycin against L. pneumophila. We found no direct effect of methylprednisolone on the intracellular antibacterial activity of either erythomycin or clindamycin.
| Original language | English |
|---|---|
| Pages (from-to) | 901-908 |
| Number of pages | 8 |
| Journal | Journal of Antimicrobial Chemotherapy |
| Volume | 31 |
| Issue number | 6 |
| Publication status | Published - 1993 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Microbiology
- Pharmacology
Cite this
Influence of methylprednisolone on the intracellular antimicrobial activity of erythromycin and clindamycin against Legionella pneumophila. / Higa, F.; Saito, A.; Inadome, J.; Kusano, Nobuchika; Kitsukawa, K.
In: Journal of Antimicrobial Chemotherapy, Vol. 31, No. 6, 1993, p. 901-908.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Influence of methylprednisolone on the intracellular antimicrobial activity of erythromycin and clindamycin against Legionella pneumophila
AU - Higa, F.
AU - Saito, A.
AU - Inadome, J.
AU - Kusano, Nobuchika
AU - Kitsukawa, K.
PY - 1993
Y1 - 1993
N2 - We have investigated the effect of methylprednisolone on the intracellular activity of erythromycin and clindamycin in vitro. An assay system was developed for the determination of intracellular activity of antibiotics against Legionella pneumophila using guinea pig resident alveolar macrophages. Erythromycin at a concentration of 0.625 mg/L (5 x MIC) and clindamycin at a concentration of 8 mg/L (MIC) inhibited the growth of a single strain of L. pneumophila in macrophages, whilst ceftizoxime at a concentration of 0.625 mg/L (5 x MIC) did not. Methylprednisolone at therapeutic concentrations did not affect the intracellular antibacterial activity of either erythromycin or clindamycin against L. pneumophila. We found no direct effect of methylprednisolone on the intracellular antibacterial activity of either erythomycin or clindamycin.
AB - We have investigated the effect of methylprednisolone on the intracellular activity of erythromycin and clindamycin in vitro. An assay system was developed for the determination of intracellular activity of antibiotics against Legionella pneumophila using guinea pig resident alveolar macrophages. Erythromycin at a concentration of 0.625 mg/L (5 x MIC) and clindamycin at a concentration of 8 mg/L (MIC) inhibited the growth of a single strain of L. pneumophila in macrophages, whilst ceftizoxime at a concentration of 0.625 mg/L (5 x MIC) did not. Methylprednisolone at therapeutic concentrations did not affect the intracellular antibacterial activity of either erythromycin or clindamycin against L. pneumophila. We found no direct effect of methylprednisolone on the intracellular antibacterial activity of either erythomycin or clindamycin.
UR - http://www.scopus.com/inward/record.url?scp=0027313670&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027313670&partnerID=8YFLogxK
M3 - Article
C2 - 8360127
AN - SCOPUS:0027313670
VL - 31
SP - 901
EP - 908
JO - Journal of Antimicrobial Chemotherapy
JF - Journal of Antimicrobial Chemotherapy
SN - 0305-7453
IS - 6
ER -