Abstract
Background: Smoking is the most important cause of chronic obstructive pulmonary disease (COPD). However, the influence of cigarette smoking on the pathogenesis of asthma in the elderly remains controversial. This study attempted to clarify the influence of cigarette smoking on elderly asthmatics. Methods: Forty-eight asthmatics over 70 years old (25 ex-smokers and 23 never-smokers) and 20 patients with COPD over 70 years old (all ex-smokers) were studied to determine the influence of cigarette smoking on IgE-mediated allergy (total IgE, IgE antibodies against inhalant allergens, bronchial hyper-responsiveness (BHR), generation of leukotriene (LT) B4 and C4), pulmonary function, and the relative area of lung showing attenuation values less than - 950 Hounsfield units (RA950) on high-resolution computed tomography scans. Results: The incidence of positive IgE antibodies against inhalant allergens, BHR, and the generation of leukotriene B4 (LTB4) by leucocytes were significantly increased in patients with a history of smoking compared with those without. Residual volume (%RV) was significantly increased, and diffusing capacity for carbon monoxide was significantly decreased in ex-smokers with asthma and COPD compared with never-smokers with asthma. Inspiratory RA950 and ratio of expiratory RA950 to inspiratory RA950 were significantly larger in asthmatics with a smoking history than in those without, and in COPD patients than in asthmatics. Conclusion: Cigarette smoking enhances the production of IgE antibodies, BHR, and generation of LTB 4 by leucocytes in elderly asthmatics. Increased hyper-inflation or emphysematous changes of the lungs expressed by increased RA950, closely related to %RV, was more frequently observed in exsmokers compared with never-smokers.
| Original language | English |
|---|---|
| Pages (from-to) | 59-64 |
| Number of pages | 6 |
| Journal | Clinical and Experimental Allergy |
| Volume | 34 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 2004 |
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Keywords
- Cigarette smoking
- Elderly asthmatics
- IgE-mediated allergy
ASJC Scopus subject areas
- Immunology
Cite this
Influence of long-term cigarette smoking on immunoglobulin E-mediated allergy, pulmonary function, and high-resolution computed tomography lung densitometry in elderly patients with asthma. / Mitsunobu, Fumihiro; Ashida, Kozo; Hosaki, Y.; Tsugeno, H.; Okamoto, M.; Nishida, N.; Nagata, T.; Tanizaki, Y.; Tanimoto, M.
In: Clinical and Experimental Allergy, Vol. 34, No. 1, 01.2004, p. 59-64.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Influence of long-term cigarette smoking on immunoglobulin E-mediated allergy, pulmonary function, and high-resolution computed tomography lung densitometry in elderly patients with asthma
AU - Mitsunobu, Fumihiro
AU - Ashida, Kozo
AU - Hosaki, Y.
AU - Tsugeno, H.
AU - Okamoto, M.
AU - Nishida, N.
AU - Nagata, T.
AU - Tanizaki, Y.
AU - Tanimoto, M.
PY - 2004/1
Y1 - 2004/1
N2 - Background: Smoking is the most important cause of chronic obstructive pulmonary disease (COPD). However, the influence of cigarette smoking on the pathogenesis of asthma in the elderly remains controversial. This study attempted to clarify the influence of cigarette smoking on elderly asthmatics. Methods: Forty-eight asthmatics over 70 years old (25 ex-smokers and 23 never-smokers) and 20 patients with COPD over 70 years old (all ex-smokers) were studied to determine the influence of cigarette smoking on IgE-mediated allergy (total IgE, IgE antibodies against inhalant allergens, bronchial hyper-responsiveness (BHR), generation of leukotriene (LT) B4 and C4), pulmonary function, and the relative area of lung showing attenuation values less than - 950 Hounsfield units (RA950) on high-resolution computed tomography scans. Results: The incidence of positive IgE antibodies against inhalant allergens, BHR, and the generation of leukotriene B4 (LTB4) by leucocytes were significantly increased in patients with a history of smoking compared with those without. Residual volume (%RV) was significantly increased, and diffusing capacity for carbon monoxide was significantly decreased in ex-smokers with asthma and COPD compared with never-smokers with asthma. Inspiratory RA950 and ratio of expiratory RA950 to inspiratory RA950 were significantly larger in asthmatics with a smoking history than in those without, and in COPD patients than in asthmatics. Conclusion: Cigarette smoking enhances the production of IgE antibodies, BHR, and generation of LTB 4 by leucocytes in elderly asthmatics. Increased hyper-inflation or emphysematous changes of the lungs expressed by increased RA950, closely related to %RV, was more frequently observed in exsmokers compared with never-smokers.
AB - Background: Smoking is the most important cause of chronic obstructive pulmonary disease (COPD). However, the influence of cigarette smoking on the pathogenesis of asthma in the elderly remains controversial. This study attempted to clarify the influence of cigarette smoking on elderly asthmatics. Methods: Forty-eight asthmatics over 70 years old (25 ex-smokers and 23 never-smokers) and 20 patients with COPD over 70 years old (all ex-smokers) were studied to determine the influence of cigarette smoking on IgE-mediated allergy (total IgE, IgE antibodies against inhalant allergens, bronchial hyper-responsiveness (BHR), generation of leukotriene (LT) B4 and C4), pulmonary function, and the relative area of lung showing attenuation values less than - 950 Hounsfield units (RA950) on high-resolution computed tomography scans. Results: The incidence of positive IgE antibodies against inhalant allergens, BHR, and the generation of leukotriene B4 (LTB4) by leucocytes were significantly increased in patients with a history of smoking compared with those without. Residual volume (%RV) was significantly increased, and diffusing capacity for carbon monoxide was significantly decreased in ex-smokers with asthma and COPD compared with never-smokers with asthma. Inspiratory RA950 and ratio of expiratory RA950 to inspiratory RA950 were significantly larger in asthmatics with a smoking history than in those without, and in COPD patients than in asthmatics. Conclusion: Cigarette smoking enhances the production of IgE antibodies, BHR, and generation of LTB 4 by leucocytes in elderly asthmatics. Increased hyper-inflation or emphysematous changes of the lungs expressed by increased RA950, closely related to %RV, was more frequently observed in exsmokers compared with never-smokers.
KW - Cigarette smoking
KW - Elderly asthmatics
KW - IgE-mediated allergy
UR - http://www.scopus.com/inward/record.url?scp=0842334825&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0842334825&partnerID=8YFLogxK
U2 - 10.1111/j.1365-2222.2004.01844.x
DO - 10.1111/j.1365-2222.2004.01844.x
M3 - Article
C2 - 14720263
AN - SCOPUS:0842334825
VL - 34
SP - 59
EP - 64
JO - Clinical and Experimental Allergy
JF - Clinical and Experimental Allergy
SN - 0954-7894
IS - 1
ER -