We studied the influence of imipramine on the duration of immobility in chronic forced-swim-stressed rats. Both single and chronic administration of imipramine potently shortened immobility in naïve rats during forced-swim testing. However, chronic, 14-day forced-swim stress testing blocked the immobility-decreasing effect induced by a single administration of imipramine. When imipramine was administered for 14 days concurrently with forced-swim stress testing, immobility was shortened significantly. From the viewpoint of imipramine's effect, these findings suggest that chronic forced-swim stress testing in rats may be an effective animal model for depression.
|Number of pages||4|
|Journal||Acta medica Okayama|
|Publication status||Published - Dec 1 2004|
- Animal model
- Forced-swim test
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)