Influence of imipramine on the duration of immobility in chronic forced-swim-stressed rats

Yoshihisa Kitamura, Hiroaki Araki, Tadashi Nagatani, Katsuyuki Takao, Kazuhiko Shibata, Yutaka Gomita

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

We studied the influence of imipramine on the duration of immobility in chronic forced-swim-stressed rats. Both single and chronic administration of imipramine potently shortened immobility in naïve rats during forced-swim testing. However, chronic, 14-day forced-swim stress testing blocked the immobility-decreasing effect induced by a single administration of imipramine. When imipramine was administered for 14 days concurrently with forced-swim stress testing, immobility was shortened significantly. From the viewpoint of imipramine's effect, these findings suggest that chronic forced-swim stress testing in rats may be an effective animal model for depression.

Original languageEnglish
Pages (from-to)271-274
Number of pages4
JournalActa Medica Okayama
Volume58
Issue number6
Publication statusPublished - Dec 2004

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Imipramine
Rats
Testing
Animals
Animal Models

Keywords

  • Animal model
  • Depression
  • Forced-swim test
  • Imipramine
  • Stress

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Kitamura, Y., Araki, H., Nagatani, T., Takao, K., Shibata, K., & Gomita, Y. (2004). Influence of imipramine on the duration of immobility in chronic forced-swim-stressed rats. Acta Medica Okayama, 58(6), 271-274.

Influence of imipramine on the duration of immobility in chronic forced-swim-stressed rats. / Kitamura, Yoshihisa; Araki, Hiroaki; Nagatani, Tadashi; Takao, Katsuyuki; Shibata, Kazuhiko; Gomita, Yutaka.

In: Acta Medica Okayama, Vol. 58, No. 6, 12.2004, p. 271-274.

Research output: Contribution to journalArticle

Kitamura, Y, Araki, H, Nagatani, T, Takao, K, Shibata, K & Gomita, Y 2004, 'Influence of imipramine on the duration of immobility in chronic forced-swim-stressed rats', Acta Medica Okayama, vol. 58, no. 6, pp. 271-274.
Kitamura Y, Araki H, Nagatani T, Takao K, Shibata K, Gomita Y. Influence of imipramine on the duration of immobility in chronic forced-swim-stressed rats. Acta Medica Okayama. 2004 Dec;58(6):271-274.
Kitamura, Yoshihisa ; Araki, Hiroaki ; Nagatani, Tadashi ; Takao, Katsuyuki ; Shibata, Kazuhiko ; Gomita, Yutaka. / Influence of imipramine on the duration of immobility in chronic forced-swim-stressed rats. In: Acta Medica Okayama. 2004 ; Vol. 58, No. 6. pp. 271-274.
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