Influence of imipramine on the duration of immobility in chronic forced-swim-stressed rats

Yoshihisa Kitamura, Hiroaki Araki, Tadashi Nagatani, Katsuyuki Takao, Kazuhiko Shibata, Yutaka Gomita

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

We studied the influence of imipramine on the duration of immobility in chronic forced-swim-stressed rats. Both single and chronic administration of imipramine potently shortened immobility in naïve rats during forced-swim testing. However, chronic, 14-day forced-swim stress testing blocked the immobility-decreasing effect induced by a single administration of imipramine. When imipramine was administered for 14 days concurrently with forced-swim stress testing, immobility was shortened significantly. From the viewpoint of imipramine's effect, these findings suggest that chronic forced-swim stress testing in rats may be an effective animal model for depression.

Original languageEnglish
Pages (from-to)271-274
Number of pages4
JournalActa medica Okayama
Volume58
Issue number6
Publication statusPublished - Dec 1 2004

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Keywords

  • Animal model
  • Depression
  • Forced-swim test
  • Imipramine
  • Stress

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Kitamura, Y., Araki, H., Nagatani, T., Takao, K., Shibata, K., & Gomita, Y. (2004). Influence of imipramine on the duration of immobility in chronic forced-swim-stressed rats. Acta medica Okayama, 58(6), 271-274.