Influence of age and gender on iodine-123 MIBG kinetics in normal lung

Noriko Kanzaki, Ryo Soda, Kiyoshi Takahashi, Keiko Sato, Toshiyuki Hayabara, Masayoshi Kibata, Yoshihiro Takeda, Yoshio Hiraki

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Abstract

Iodine-123 MIBG is a biochemical marker that can be used to monitor pulmonary norepinephrine (NE) metabolism. The purpose of this study was to characterize pulmonary I-123 MIBG kinetics in relation to age and gender. Materials and Methods: Seventeen healthy volunteers and 14 patients with no cardiac or pulmonary disorders were included in this study (age range: 24 to 88 years, mean age 50.2 ± 17.6 years; 16 males, 15 females). Planar images were obtained 15 min (early) and 3 h (delayed) after injection of I-123 MIBG (111 MBq). Pulmonary uptake of I-123 MIBG was quantified based on the lung- to-mediastinum ratio (LMR) on early and delayed images. The lung clearance rate (LCR) was calculated from both the early and delayed images. Results: Both early and delayed LMR values increased slightly, although they showed no significant correlations with age. There was a significant inverse correlation between LCR and age (r = -0.57, p < 0.001). Neither LCR nor LMR differed significantly between male and female patients, but the mean age of the men was lower than that of the women. Conclusions: Pulmonary I-123 MIBG kinetics may reflect age-dependent changes in NE metabolism. The effects of age should be taken into account when assessing pulmonary NE metabolism with I-123 MIBG.

Original languageEnglish
Pages (from-to)225-229
Number of pages5
JournalAnnals of nuclear medicine
Volume12
Issue number4
DOIs
Publication statusPublished - Jan 1 1998

Keywords

  • Endothelial cell
  • I-123 MIBG
  • Lung uptake
  • Norepinephrine metabolism

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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    Kanzaki, N., Soda, R., Takahashi, K., Sato, K., Hayabara, T., Kibata, M., Takeda, Y., & Hiraki, Y. (1998). Influence of age and gender on iodine-123 MIBG kinetics in normal lung. Annals of nuclear medicine, 12(4), 225-229. https://doi.org/10.1007/BF03164851