Influence of a single-nucleotide polymorphism of the DNA mismatch repair-related gene exonuclease-1 (rs9350) with prostate cancer risk among Chinese people

Yiming Zhang, Pengju Li, Abai Xu, Jie Chen, Chao Ma, Akiko Sakai, Liping Xie, Lei Wang, Yanqun Na, Haruki Kaku, Peng Xu, Zhong Jin, Xiezhao Li, Kai Guo, Haiyan Shen, Shaobo Zheng, Hiromi Kumon, Chunxiao Liu, Peng Huang

Research output: Contribution to journalArticle

Abstract

In this study, we aimed to identify the influence of exonuclease 1 (EXO1) single-nucleotide polymorphism rs9350, which is involved in DNA mismatch repair, on prostate cancer risk in Chinese people. In our hospital-based case–control study, 214 prostate cancer patients and 253 cancer-free control subjects were enrolled from three hospitals in China. Genotyping for rs9350 was performed by the SNaPshot® method using peripheral blood samples. Consequently, a significantly higher prostate cancer risk was observed in patients with the CC genotype [odds ratio (OR) = 1.678, 95 % confidence interval (CI) = 1.130–2.494, P = 0.010] than in those with the CT genotype. Further, the CT/TT genotypes were significantly associated with increased prostate cancer risk (adjusted OR = 1.714, 95 % CI = 1.176–2.500, P = 0.005), and the C allele had a statistically significant compared with T allele (P = 0.009) of EXO1 (rs9350). Through stratified analysis, significant associations were revealed for the CT/TT genotype in the subgroup with diagnosis age >72 (adjusted OR = 1.776, 95 % CI = 1.051–3.002, P = 0.032) and in patients with localized disease subgroup (adjusted OR = 1.798, 95 % CI = 1.070–3.022, P = 0.027). In addition, we observed that patients with prostate-specific antigen (PSA) levels of ≤10 ng/mL were more likely to have the CT/TT genotypes than those with PSA levels of >10 ng/mL (P = 0.006). For the first time, we present evidence that the inherited EXO1 polymorphism rs9350 may have a substantial influence on prostate cancer risk in Chinese people. We believe that the rs9350 could be a useful biomarker for assessing predisposition for and early diagnosis of prostate cancer.

Original languageEnglish
Pages (from-to)6653-6659
Number of pages7
JournalTumor Biology
Volume37
Issue number5
DOIs
Publication statusPublished - May 1 2016

Keywords

  • DNA mismatch repair
  • EXO1
  • Prostate cancer
  • Single-nucleotide polymorphisms
  • rs9350

ASJC Scopus subject areas

  • Cancer Research

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