Inflammatory fibrous histiocytoma presenting leukemoid reaction

K. Takahashi, Y. Kimura, M. Naito, Teizo Yoshimura, H. Uchida, S. Araki

Research output: Contribution to journalArticle

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Abstract

A case of inflammatory fibrous histiocytoma presenting leukemoid reaction is reported. A tumor had developed at the right scapular region 10 years ago and recurred twice with fever and leukocytosis, and finally with leukemoid reaction. Besides the histopathological features typical of malignant fibrous histiocytoma, this tumor showed prominent and diffuse infiltration of neutrophilic leukocytes. Hematologic examination of the bone marrow aspirates disclosed myeloid hyperplasia. Bacteriological examination revealed no pathogenic microorganisms in the tumor tissue. Chemotactic activity of the neutrophilic leukocytes was demonstrated in the extract obtained from the tumor, and subcutaneous injection of the extract into rats induced myeloid hyperplasia in the bone marrow and neutrophil infiltration in the liver and spleen of the animals. These results suggest the possibility of the case as a colony-stimulating factor-producing tumor.

Original languageEnglish
Pages (from-to)498-506
Number of pages9
JournalPathology Research and Practice
Volume184
Issue number5
Publication statusPublished - 1989
Externally publishedYes

Fingerprint

Leukemoid Reaction
Benign Fibrous Histiocytoma
Neoplasms
Hyperplasia
Leukocytes
Bone Marrow Examination
Colony-Stimulating Factors
Malignant Fibrous Histiocytoma
Neutrophil Infiltration
Leukocytosis
Subcutaneous Injections
Fever
Spleen
Bone Marrow
Liver

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Takahashi, K., Kimura, Y., Naito, M., Yoshimura, T., Uchida, H., & Araki, S. (1989). Inflammatory fibrous histiocytoma presenting leukemoid reaction. Pathology Research and Practice, 184(5), 498-506.

Inflammatory fibrous histiocytoma presenting leukemoid reaction. / Takahashi, K.; Kimura, Y.; Naito, M.; Yoshimura, Teizo; Uchida, H.; Araki, S.

In: Pathology Research and Practice, Vol. 184, No. 5, 1989, p. 498-506.

Research output: Contribution to journalArticle

Takahashi, K, Kimura, Y, Naito, M, Yoshimura, T, Uchida, H & Araki, S 1989, 'Inflammatory fibrous histiocytoma presenting leukemoid reaction', Pathology Research and Practice, vol. 184, no. 5, pp. 498-506.
Takahashi K, Kimura Y, Naito M, Yoshimura T, Uchida H, Araki S. Inflammatory fibrous histiocytoma presenting leukemoid reaction. Pathology Research and Practice. 1989;184(5):498-506.
Takahashi, K. ; Kimura, Y. ; Naito, M. ; Yoshimura, Teizo ; Uchida, H. ; Araki, S. / Inflammatory fibrous histiocytoma presenting leukemoid reaction. In: Pathology Research and Practice. 1989 ; Vol. 184, No. 5. pp. 498-506.
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