Abstract
A case of inflammatory fibrous histiocytoma presenting leukemoid reaction is reported. A tumor had developed at the right scapular region 10 years ago and recurred twice with fever and leukocytosis, and finally with leukemoid reaction. Besides the histopathological features typical of malignant fibrous histiocytoma, this tumor showed prominent and diffuse infiltration of neutrophilic leukocytes. Hematologic examination of the bone marrow aspirates disclosed myeloid hyperplasia. Bacteriological examination revealed no pathogenic microorganisms in the tumor tissue. Chemotactic activity of the neutrophilic leukocytes was demonstrated in the extract obtained from the tumor, and subcutaneous injection of the extract into rats induced myeloid hyperplasia in the bone marrow and neutrophil infiltration in the liver and spleen of the animals. These results suggest the possibility of the case as a colony-stimulating factor-producing tumor.
| Original language | English |
|---|---|
| Pages (from-to) | 498-506 |
| Number of pages | 9 |
| Journal | Pathology Research and Practice |
| Volume | 184 |
| Issue number | 5 |
| Publication status | Published - 1989 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Pathology and Forensic Medicine
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Inflammatory fibrous histiocytoma presenting leukemoid reaction. / Takahashi, K.; Kimura, Y.; Naito, M.; Yoshimura, Teizo; Uchida, H.; Araki, S.
In: Pathology Research and Practice, Vol. 184, No. 5, 1989, p. 498-506.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Inflammatory fibrous histiocytoma presenting leukemoid reaction
AU - Takahashi, K.
AU - Kimura, Y.
AU - Naito, M.
AU - Yoshimura, Teizo
AU - Uchida, H.
AU - Araki, S.
PY - 1989
Y1 - 1989
N2 - A case of inflammatory fibrous histiocytoma presenting leukemoid reaction is reported. A tumor had developed at the right scapular region 10 years ago and recurred twice with fever and leukocytosis, and finally with leukemoid reaction. Besides the histopathological features typical of malignant fibrous histiocytoma, this tumor showed prominent and diffuse infiltration of neutrophilic leukocytes. Hematologic examination of the bone marrow aspirates disclosed myeloid hyperplasia. Bacteriological examination revealed no pathogenic microorganisms in the tumor tissue. Chemotactic activity of the neutrophilic leukocytes was demonstrated in the extract obtained from the tumor, and subcutaneous injection of the extract into rats induced myeloid hyperplasia in the bone marrow and neutrophil infiltration in the liver and spleen of the animals. These results suggest the possibility of the case as a colony-stimulating factor-producing tumor.
AB - A case of inflammatory fibrous histiocytoma presenting leukemoid reaction is reported. A tumor had developed at the right scapular region 10 years ago and recurred twice with fever and leukocytosis, and finally with leukemoid reaction. Besides the histopathological features typical of malignant fibrous histiocytoma, this tumor showed prominent and diffuse infiltration of neutrophilic leukocytes. Hematologic examination of the bone marrow aspirates disclosed myeloid hyperplasia. Bacteriological examination revealed no pathogenic microorganisms in the tumor tissue. Chemotactic activity of the neutrophilic leukocytes was demonstrated in the extract obtained from the tumor, and subcutaneous injection of the extract into rats induced myeloid hyperplasia in the bone marrow and neutrophil infiltration in the liver and spleen of the animals. These results suggest the possibility of the case as a colony-stimulating factor-producing tumor.
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UR - http://www.scopus.com/inward/citedby.url?scp=0024406457&partnerID=8YFLogxK
M3 - Article
C2 - 2546130
AN - SCOPUS:0024406457
VL - 184
SP - 498
EP - 506
JO - Pathology Research and Practice
JF - Pathology Research and Practice
SN - 0344-0338
IS - 5
ER -