Abstract
A case of inflammatory fibrous histiocytoma presenting leukemoid reaction is reported. A tumor had developed at the right scapular region 10 years ago and recurred twice with fever and leukocytosis, and finally with leukemoid reaction. Besides the histopathological features typical of malignant fibrous histiocytoma, this tumor showed prominent and diffuse infiltration of neutrophilic leukocytes. Hematologic examination of the bone marrow aspirates disclosed myeloid hyperplasia. Bacteriological examination revealed no pathogenic microorganisms in the tumor tissue. Chemotactic activity of the neutrophilic leukocytes was demonstrated in the extract obtained from the tumor, and subcutaneous injection of the extract into rats induced myeloid hyperplasia in the bone marrow and neutrophil infiltration in the liver and spleen of the animals. These results suggest the possibility of the case as a colony-stimulating factor-producing tumor.
| Original language | English |
|---|---|
| Pages (from-to) | 498-506 |
| Number of pages | 9 |
| Journal | Pathology Research and Practice |
| Volume | 184 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - Jan 1 1989 |
| Externally published | Yes |
Keywords
- Inflammatory fibrous histiocytoma
- Leukemoid reaction
- Myeloid hyperplasia
- Neutrophil chemotactic activity
- Neutrophil infiltration
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Cell Biology