Inflammation and the pathogenesis of diabetic nephropathy

Research output: Contribution to journalArticle

297 Citations (Scopus)

Abstract

The most problematic issue in clinical nephrology is the relentless and progressive increase in patients with ESRD (end-stage renal disease) worldwide. The impact of diabetic nephropathy on the increasing population with CKD (chronic kidney disease) and ESRD is enormous. Three major pathways showing abnormality of intracellular metabolism have been identified in the development of diabetic nephropathy: (i) the activation of polyol and PKC (protein kinase C) pathways; (ii) the formation of advanced glycation end-products; and (iii) intraglomerular hypertension induced by glomerular hyperfiltration. Upstream of these three major pathways, hyperglycaemia is the major driving force of the progression to ESRD from diabetic nephropathy. Downstream of the three pathways, microinflammation and subsequent extracellular matrix expansion are common pathways for the progression of diabetic nephropathy. In recent years, many researchers have been convinced that the inflammation pathways play central roles in the progression of diabetic nephropathy, and the identification of new inflammatory molecules may link to the development of new therapeutic strategies. Various molecules related to the inflammation pathways in diabetic nephropathy include transcription factors, pro-inflammatory cytokines, chemokines, adhesion molecules, Toll-like receptors, adipokines and nuclear receptors, which are candidates for the new molecular targets for the treatment of diabetic nephropathy. Understanding of these molecular pathways of inflammation would translate into the development of anti-inflammation therapeutic strategies.

Original languageEnglish
Pages (from-to)139-152
Number of pages14
JournalClinical Science
Volume124
Issue number3
DOIs
Publication statusPublished - Feb 2013

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Diabetic Nephropathies
Inflammation
Chronic Kidney Failure
Advanced Glycosylation End Products
Adipokines
Nephrology
Toll-Like Receptors
Cytoplasmic and Nuclear Receptors
Chronic Renal Insufficiency
Chemokines
Hyperglycemia
Protein Kinase C
Extracellular Matrix
Transcription Factors
Therapeutics
Research Personnel
Cytokines
Hypertension
Population

Keywords

  • Adhesion molecule
  • Adipokine
  • Chemokine
  • Cytokine
  • Diabetic nephropathy
  • Nuclear receptor
  • Transcription factor

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Inflammation and the pathogenesis of diabetic nephropathy. / Wada, Jun; Makino, Hirofumi.

In: Clinical Science, Vol. 124, No. 3, 02.2013, p. 139-152.

Research output: Contribution to journalArticle

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