Infection of a human retinal pigment epithelial cell line with human herpesvirus 6 variant A

Yujiro Arao, Sumi Soushi, Yuko Sato, Eiko Moriishi, Yasutaka Ando, Masao Yamada, Jorge Padilla, Fumio Uno, Shiro Nii, Takeshi Kurata

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

A retinal pigment epithelial (RPE) cell line (K-1034) was examined for its susceptibility to human herpesvirus 6 variant A (HHV-6A). Exposure of K-1034 cells to HHV-6A induced the formation of multinucleated giant cells, which was suppressed by an inhibitor of viral DNA synthesis. In the giant cells, herpesvirus nucleocapsids were demonstrated by electron microscopy and the viral glycoprotein B was detected by immunofluorescence assay. These results indicate that K-1034 cells are susceptible to HHV-6A and suggest that HHV-6A has an ability to directly destroy epithelial cells.

Original languageEnglish
Pages (from-to)105-110
Number of pages6
JournalJournal of Medical Virology
Volume53
Issue number2
DOIs
Publication statusPublished - Oct 1 1997

Keywords

  • Human herpesvirus 6
  • Lymphotropic betaherpesvirus
  • Retinal pigment epithelial cells

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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