INFANTILE MYOFIBROMATOSIS:Report of Two Cases

Kohichi Mizobuchi, Tadashi Yoshino, Ikuko Ikehara, Kenji Kawabata, Akira Tsutsumi, Katsuo Ogawa, Takashi Saku

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

Two cases of infantile myofibromatosis were presented. Case 1 was a 6‐month‐old girl with multiple nodular lesions in the left parietal bone, dermis of abdominal wall, chest wall, right upper arm, and bilateral femur. Case 2 was a 12‐month‐old girl with solitary nodular lesions in the left parietal bone having a tendency to enlarge. Histologically, these tumorous lesions consisted of broad bundles of well oriented spindle‐shaped cells superficially resembling smooth muscle tissue. In electron microscopy, the constituent cells combined ultrastructural characteristics of both fibroblasts and smooth muscle cells., Immunoperoxidase method showed that anti‐smooth muscle antibodies binded to the cytoplasm of the bundle forming cells. From these results, it may be concluded that the lesion consisted of pure proliferation of myofibroblasts, and its peculiar growth behavior was discussed, though the histogenesis still remains obscure. ACTA PATHOL. JPN. 36: 1411–1418, 1986.

Original languageEnglish
Pages (from-to)1411-1418
Number of pages8
JournalPathology International
Volume36
Issue number9
DOIs
Publication statusPublished - Sep 1986

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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