Ineffectiveness of daptomycin in the treatment of septic pulmonary emboli and persistent bacteremia caused by methicillin-resistant Staphylococcus aureus

Hideharu Hagiya, Shingo Hagioka, Fumio Otsuka

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A 73-year-old man with long-term food deprivation and total parenteral nutrition was diagnosed with septic pulmonary emboli (SPE) and a persistent bacteremia caused by central line-associated blood stream methicillin-resistant Staphylococcus aureus (MRSA) infection. Although daptomycin (DAP) failed to treat the persistent bacteremia, linezolid successfully controlled it. DAP is inactivated by lung surfactant, and therefore, it should not be administered for lower respiratory infections. However, SPE caused by MRSA has been reported to be treatable with DAP since it is an infection of the lung parenchyma. We herein report the lack of effect of daptomycin in SPE treatment.

Original languageEnglish
Pages (from-to)2577-2582
Number of pages6
JournalInternal Medicine
Volume52
Issue number22
DOIs
Publication statusPublished - 2013

Fingerprint

Daptomycin
Methicillin-Resistant Staphylococcus aureus
Bacteremia
Embolism
Lung
Linezolid
Therapeutics
Food Deprivation
Total Parenteral Nutrition
Infection
Surface-Active Agents
Respiratory Tract Infections

Keywords

  • Central line-associated blood stream infection
  • Daptomycin
  • Linezolid
  • Methicillin-resistant staphylococcus aureus
  • Septic pulmonary emboli
  • Suppurative thrombophlebitis

ASJC Scopus subject areas

  • Internal Medicine

Cite this

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abstract = "A 73-year-old man with long-term food deprivation and total parenteral nutrition was diagnosed with septic pulmonary emboli (SPE) and a persistent bacteremia caused by central line-associated blood stream methicillin-resistant Staphylococcus aureus (MRSA) infection. Although daptomycin (DAP) failed to treat the persistent bacteremia, linezolid successfully controlled it. DAP is inactivated by lung surfactant, and therefore, it should not be administered for lower respiratory infections. However, SPE caused by MRSA has been reported to be treatable with DAP since it is an infection of the lung parenchyma. We herein report the lack of effect of daptomycin in SPE treatment.",
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