Ineffectiveness of daptomycin in the treatment of septic pulmonary emboli and persistent bacteremia caused by methicillin-resistant Staphylococcus aureus

Hideharu Hagiya; Shingo Hagioka; Fumio Otsuka

doi:10.2169/internalmedicine.52.0023

Ineffectiveness of daptomycin in the treatment of septic pulmonary emboli and persistent bacteremia caused by methicillin-resistant Staphylococcus aureus

Hideharu Hagiya, Shingo Hagioka, Fumio Otsuka

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

A 73-year-old man with long-term food deprivation and total parenteral nutrition was diagnosed with septic pulmonary emboli (SPE) and a persistent bacteremia caused by central line-associated blood stream methicillin-resistant Staphylococcus aureus (MRSA) infection. Although daptomycin (DAP) failed to treat the persistent bacteremia, linezolid successfully controlled it. DAP is inactivated by lung surfactant, and therefore, it should not be administered for lower respiratory infections. However, SPE caused by MRSA has been reported to be treatable with DAP since it is an infection of the lung parenchyma. We herein report the lack of effect of daptomycin in SPE treatment.

Original language	English
Pages (from-to)	2577-2582
Number of pages	6
Journal	Internal Medicine
Volume	52
Issue number	22
DOIs	https://doi.org/10.2169/internalmedicine.52.0023
Publication status	Published - 2013

Keywords

Central line-associated blood stream infection
Daptomycin
Linezolid
Methicillin-resistant staphylococcus aureus
Septic pulmonary emboli
Suppurative thrombophlebitis

ASJC Scopus subject areas

Internal Medicine

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10.2169/internalmedicine.52.0023

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title = "Ineffectiveness of daptomycin in the treatment of septic pulmonary emboli and persistent bacteremia caused by methicillin-resistant Staphylococcus aureus",

abstract = "A 73-year-old man with long-term food deprivation and total parenteral nutrition was diagnosed with septic pulmonary emboli (SPE) and a persistent bacteremia caused by central line-associated blood stream methicillin-resistant Staphylococcus aureus (MRSA) infection. Although daptomycin (DAP) failed to treat the persistent bacteremia, linezolid successfully controlled it. DAP is inactivated by lung surfactant, and therefore, it should not be administered for lower respiratory infections. However, SPE caused by MRSA has been reported to be treatable with DAP since it is an infection of the lung parenchyma. We herein report the lack of effect of daptomycin in SPE treatment.",

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AU - Hagioka, Shingo

AU - Otsuka, Fumio

PY - 2013

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Ineffectiveness of daptomycin in the treatment of septic pulmonary emboli and persistent bacteremia caused by methicillin-resistant Staphylococcus aureus

Abstract

Keywords

ASJC Scopus subject areas

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