Induction of two species of superoxide dismutase in some organs of rats by low dose X-irradiation.

Kiyonori Yamaoka, E. F. Sato, K. Utsumi

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Four hours after 0.25 Gy X-irradiation, the enzymatic activity of copper and zinc activated superoxide dismutase (Cu/Zn-SOD) in the spleen of mature rats showed a significant quantitative increase (by 25%); this was accompanied by a marked increase (by 70%) in the mRNA for this enzyme as compared to the control (sham irradiation) group. Irradiation had no effect on the enzymatic activity of manganese activated superoxide dismutase (Mn-SOD). Moreover, the expression of the mRNA for Mn-SOD was similar to that of the unirradiated control group. On the other hand, the enzymatic activity of both Cu/Zn-SOD and Mn-SOD in the liver of fetal rats showed a significant quantitative increase (by 15-35%); the expression of the mRNA for the two species of SOD increased (by 20-30%) at 4 hours after 1 Gy X-irradiation as compared to the control group. These findings suggest that the increase in SODmRNA level is due to novel transcription of SODmRNA by low dose irradiation.

Original languageEnglish
Pages (from-to)205-214
Number of pages10
JournalPhysiological Chemistry and Physics and Medical NMR
Volume26
Issue number3
Publication statusPublished - 1994
Externally publishedYes

Fingerprint

Superoxide Dismutase
Dosimetry
Rats
Irradiation
Manganese
Messenger RNA
Control Groups
Zinc
Copper
Spleen
Transcription
Liver
Enzymes
Superoxide Dismutase-1

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Biophysics
  • Physiology
  • Physiology (medical)
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Induction of two species of superoxide dismutase in some organs of rats by low dose X-irradiation. / Yamaoka, Kiyonori; Sato, E. F.; Utsumi, K.

In: Physiological Chemistry and Physics and Medical NMR, Vol. 26, No. 3, 1994, p. 205-214.

Research output: Contribution to journalArticle

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