Induction of trypsin-induced hyperexcitability in the rat hippocampal slice is blocked by the N-methyl-d-aspartate receptor antagonist, MK-801

Norihito Yamada, David K. Bilkey

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Bath application of trypsin (0.05%,type I) gave rise to epileptiform activities in CA1 of the rat hippocampal slice. A non-competitive antagonist of N-methyl-d-aspartate (NMDA) receptors, MK-801, blocked the induction of the epileptiform activity, whereas a competitive antagonist, d-APV, showed weak antagonism on the induction of the epileptiform activity. These results may lead us to the understanding of the role of NMDA receptors in the neurotoxic action of trypsin.

Original languageEnglish
Pages (from-to)336-338
Number of pages3
JournalBrain Research
Volume624
Issue number1-2
DOIs
Publication statusPublished - Oct 8 1993
Externally publishedYes

Keywords

  • Epileptiform
  • Hippocampal slice
  • NMDA
  • Trypsin

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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