Induction of trypsin-induced hyperexcitability in the rat hippocampal slice is blocked by the N-methyl-d-aspartate receptor antagonist, MK-801

Norihito Yamada; David K. Bilkey

doi:10.1016/0006-8993(93)90099-9

Induction of trypsin-induced hyperexcitability in the rat hippocampal slice is blocked by the N-methyl-d-aspartate receptor antagonist, MK-801

Norihito Yamada, David K. Bilkey

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Bath application of trypsin (0.05%,type I) gave rise to epileptiform activities in CA1 of the rat hippocampal slice. A non-competitive antagonist of N-methyl-d-aspartate (NMDA) receptors, MK-801, blocked the induction of the epileptiform activity, whereas a competitive antagonist, d-APV, showed weak antagonism on the induction of the epileptiform activity. These results may lead us to the understanding of the role of NMDA receptors in the neurotoxic action of trypsin.

Original language	English
Pages (from-to)	336-338
Number of pages	3
Journal	Brain Research
Volume	624
Issue number	1-2
DOIs	https://doi.org/10.1016/0006-8993(93)90099-9
Publication status	Published - Oct 8 1993
Externally published	Yes

Keywords

Epileptiform
Hippocampal slice
NMDA
Trypsin

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(93)90099-9

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abstract = "Bath application of trypsin (0.05%,type I) gave rise to epileptiform activities in CA1 of the rat hippocampal slice. A non-competitive antagonist of N-methyl-d-aspartate (NMDA) receptors, MK-801, blocked the induction of the epileptiform activity, whereas a competitive antagonist, d-APV, showed weak antagonism on the induction of the epileptiform activity. These results may lead us to the understanding of the role of NMDA receptors in the neurotoxic action of trypsin.",

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AU - Yamada, Norihito

AU - Bilkey, David K.

PY - 1993/10/8

Y1 - 1993/10/8

N2 - Bath application of trypsin (0.05%,type I) gave rise to epileptiform activities in CA1 of the rat hippocampal slice. A non-competitive antagonist of N-methyl-d-aspartate (NMDA) receptors, MK-801, blocked the induction of the epileptiform activity, whereas a competitive antagonist, d-APV, showed weak antagonism on the induction of the epileptiform activity. These results may lead us to the understanding of the role of NMDA receptors in the neurotoxic action of trypsin.

AB - Bath application of trypsin (0.05%,type I) gave rise to epileptiform activities in CA1 of the rat hippocampal slice. A non-competitive antagonist of N-methyl-d-aspartate (NMDA) receptors, MK-801, blocked the induction of the epileptiform activity, whereas a competitive antagonist, d-APV, showed weak antagonism on the induction of the epileptiform activity. These results may lead us to the understanding of the role of NMDA receptors in the neurotoxic action of trypsin.

KW - Epileptiform

KW - Hippocampal slice

KW - NMDA

KW - Trypsin

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Induction of trypsin-induced hyperexcitability in the rat hippocampal slice is blocked by the N-methyl-d-aspartate receptor antagonist, MK-801

Abstract

Keywords

ASJC Scopus subject areas

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