Induction of teratocarcinoma F9 cell differentiation with cis-diammine dichloroplatinum(II) (CDDP)

Toshihide Doi, Tetsuro Sumi, Yukio Nishina, Mitsuko Kosaka, Souichi A. Iwai, Masayoshi Sakuda, Yoshitake Nishimune

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6 Citations (Scopus)


cis-Diammine dichloroplatinum(II) (CDDP) is the salt of a platinum compound which has been noted to have a wide spectrum of activity against malignant disorders. We have studied the effects of CDDP on embryonal carcinoma F9 cell differentiation. In the presence of this agent in vitro, the cells showed rapid morphological changes, a marked increase in the mRNA expression of various differentiation markers accompanied by a loss of tumorigenicity. These results indicate that the differentiation of F9 cells is induced with CDDP.

Original languageEnglish
Pages (from-to)81-86
Number of pages6
JournalCancer Letters
Issue number1
Publication statusPublished - Jan 6 1995



  • CDDP
  • Differentiation
  • Teratocarcinoma F9 cell

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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