Abstract
cis-Diammine dichloroplatinum(II) (CDDP) is the salt of a platinum compound which has been noted to have a wide spectrum of activity against malignant disorders. We have studied the effects of CDDP on embryonal carcinoma F9 cell differentiation. In the presence of this agent in vitro, the cells showed rapid morphological changes, a marked increase in the mRNA expression of various differentiation markers accompanied by a loss of tumorigenicity. These results indicate that the differentiation of F9 cells is induced with CDDP.
| Original language | English |
|---|---|
| Pages (from-to) | 81-86 |
| Number of pages | 6 |
| Journal | Cancer Letters |
| Volume | 88 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 6 1995 |
| Externally published | Yes |
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Keywords
- CDDP
- Differentiation
- Teratocarcinoma F9 cell
ASJC Scopus subject areas
- Cancer Research
- Oncology
- Molecular Biology
Cite this
Induction of teratocarcinoma F9 cell differentiation with cis-diammine dichloroplatinum(II) (CDDP). / Doi, Toshihide; Sumi, Tetsuro; Nishina, Yukio; Kosaka, Mitsuko; Iwai, Souichi A.; Sakuda, Masayoshi; Nishimune, Yoshitake.
In: Cancer Letters, Vol. 88, No. 1, 06.01.1995, p. 81-86.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Induction of teratocarcinoma F9 cell differentiation with cis-diammine dichloroplatinum(II) (CDDP)
AU - Doi, Toshihide
AU - Sumi, Tetsuro
AU - Nishina, Yukio
AU - Kosaka, Mitsuko
AU - Iwai, Souichi A.
AU - Sakuda, Masayoshi
AU - Nishimune, Yoshitake
PY - 1995/1/6
Y1 - 1995/1/6
N2 - cis-Diammine dichloroplatinum(II) (CDDP) is the salt of a platinum compound which has been noted to have a wide spectrum of activity against malignant disorders. We have studied the effects of CDDP on embryonal carcinoma F9 cell differentiation. In the presence of this agent in vitro, the cells showed rapid morphological changes, a marked increase in the mRNA expression of various differentiation markers accompanied by a loss of tumorigenicity. These results indicate that the differentiation of F9 cells is induced with CDDP.
AB - cis-Diammine dichloroplatinum(II) (CDDP) is the salt of a platinum compound which has been noted to have a wide spectrum of activity against malignant disorders. We have studied the effects of CDDP on embryonal carcinoma F9 cell differentiation. In the presence of this agent in vitro, the cells showed rapid morphological changes, a marked increase in the mRNA expression of various differentiation markers accompanied by a loss of tumorigenicity. These results indicate that the differentiation of F9 cells is induced with CDDP.
KW - CDDP
KW - Differentiation
KW - Teratocarcinoma F9 cell
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UR - http://www.scopus.com/inward/citedby.url?scp=0028876650&partnerID=8YFLogxK
U2 - 10.1016/0304-3835(94)03615-P
DO - 10.1016/0304-3835(94)03615-P
M3 - Article
VL - 88
SP - 81
EP - 86
JO - Cancer Letters
JF - Cancer Letters
SN - 0304-3835
IS - 1
ER -