Induction of teratocarcinoma F9 cell differentiation with cis-diammine dichloroplatinum(II) (CDDP)

Toshihide Doi; Tetsuro Sumi; Yukio Nishina; Mitsuko Kosaka; Souichi A. Iwai; Masayoshi Sakuda; Yoshitake Nishimune

doi:10.1016/0304-3835(94)03615-P

Induction of teratocarcinoma F9 cell differentiation with cis-diammine dichloroplatinum(II) (CDDP)

Toshihide Doi, Tetsuro Sumi, Yukio Nishina, Mitsuko Kosaka, Souichi A. Iwai, Masayoshi Sakuda, Yoshitake Nishimune

Research output: Contribution to journal › Article

6 Citations (Scopus)

Abstract

cis-Diammine dichloroplatinum(II) (CDDP) is the salt of a platinum compound which has been noted to have a wide spectrum of activity against malignant disorders. We have studied the effects of CDDP on embryonal carcinoma F9 cell differentiation. In the presence of this agent in vitro, the cells showed rapid morphological changes, a marked increase in the mRNA expression of various differentiation markers accompanied by a loss of tumorigenicity. These results indicate that the differentiation of F9 cells is induced with CDDP.

Original language	English
Pages (from-to)	81-86
Number of pages	6
Journal	Cancer Letters
Volume	88
Issue number	1
DOIs	https://doi.org/10.1016/0304-3835(94)03615-P
Publication status	Published - Jan 6 1995
Externally published	Yes

Keywords

CDDP
Differentiation
Teratocarcinoma F9 cell

ASJC Scopus subject areas

Oncology
Cancer Research

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Doi, T., Sumi, T., Nishina, Y., Kosaka, M., Iwai, S. A., Sakuda, M., & Nishimune, Y. (1995). Induction of teratocarcinoma F9 cell differentiation with cis-diammine dichloroplatinum(II) (CDDP). Cancer Letters, 88(1), 81-86. https://doi.org/10.1016/0304-3835(94)03615-P

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AU - Kosaka, Mitsuko

AU - Iwai, Souichi A.

AU - Sakuda, Masayoshi

AU - Nishimune, Yoshitake

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