Induction of spermidine/spermine N-acetyltransferase by parathyroid hormone in rabbit costal chondrocytes in culture

Isao Matsui-yuasa, Shuzo Otani, Seiji Morisawa, Masaharu Takigawa, Motomi Enomoto, Fujio Suzuki

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Parathyroid hormone (PTH) increased the activity of spermidine/spermine N1-acetyltransferase, a rate-limiting enzyme of polyamine biodegradation, in rabbit costal chondrocytes in culture. The enzyme activity increased in a dose-dependent manner after addition of PTH to the culture, reaching a maximum at 8 h. The increase in the enzyme activity was abolished by cycloheximide or actinomycin D. Dibutyryl cyclic AMP also induced the acetyltransferase to some extent. These results suggest that the induction of spermidine/spermine N1-acetyltransferase by PTH may play some significant role in the expression of the differentiated pheno-type of chondrocytes.

Original languageEnglish
Pages (from-to)387-390
Number of pages4
JournalJournal of Biochemistry
Volume97
Issue number1
Publication statusPublished - Jan 1985
Externally publishedYes

Fingerprint

Acetyltransferases
Spermidine
Spermine
Rabbit
Hormones
Chondrocytes
Parathyroid Hormone
Proof by induction
Enzymes
Enzyme activity
Rabbits
Biodegradation
Polyamines
Cyclic AMP
Bucladesine
Dactinomycin
Cycloheximide
Phenotype
Dose
Limiting

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Physiology (medical)
  • Radiology Nuclear Medicine and imaging
  • Molecular Biology
  • Biochemistry

Cite this

Induction of spermidine/spermine N-acetyltransferase by parathyroid hormone in rabbit costal chondrocytes in culture. / Matsui-yuasa, Isao; Otani, Shuzo; Morisawa, Seiji; Takigawa, Masaharu; Enomoto, Motomi; Suzuki, Fujio.

In: Journal of Biochemistry, Vol. 97, No. 1, 01.1985, p. 387-390.

Research output: Contribution to journalArticle

Matsui-yuasa, I, Otani, S, Morisawa, S, Takigawa, M, Enomoto, M & Suzuki, F 1985, 'Induction of spermidine/spermine N-acetyltransferase by parathyroid hormone in rabbit costal chondrocytes in culture', Journal of Biochemistry, vol. 97, no. 1, pp. 387-390.
Matsui-yuasa, Isao ; Otani, Shuzo ; Morisawa, Seiji ; Takigawa, Masaharu ; Enomoto, Motomi ; Suzuki, Fujio. / Induction of spermidine/spermine N-acetyltransferase by parathyroid hormone in rabbit costal chondrocytes in culture. In: Journal of Biochemistry. 1985 ; Vol. 97, No. 1. pp. 387-390.
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