Induction of immediate-early genes c-fos and zif268 in the subnucleus oralis by noxious tooth pulp stimulation

Tomosada Sugimoto, Yi Fen He, Makoto Funahashi, Hiroyuki Ichikawa

Research output: Contribution to journalArticle

23 Citations (Scopus)


c-fos and zif268 expression were assessed by immunocytochemistry for c- Fos and Zif268 proteins in the sensory trigeminal nuclear complex following noxious mechanical stimulation of the mandibular incisor pulp of rats. Marked up-regulation of both immediate early genes was observed in the subnucleus oralis ipsilateral to the stimulation. Cavity preparation of the dentine without reaching the pulp did not cause significant up-regulation detectable by immunocytochemistry. These results provide evidence that noxious dental signals reach the ipsilateral subnucleus oralis and up-regulate the transcription of immediate early genes c-fos and zif268.

Original languageEnglish
Pages (from-to)353-358
Number of pages6
JournalBrain Research
Issue number2
Publication statusPublished - Jun 1 1998



  • C-fos
  • Spinal trigeminal tract nucleus
  • Subnucleus oralis
  • Tooth pulp
  • Zif268

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this