Induction of immediate-early gene proteins in dentate granule cells and somatostatin interneurons after hippocampal seizures

M. Dragunow, Norihito Yamada, D. K. Bilkey, P. Lawlor

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

The expression of the protein products of the immediate-early genes c-fos, Fos B, Fos-related proteins (FRAs), c-jun, jun B, jun D and krox-24 was investigated in the rat hippocampus at various times after electrically-induced hippocampal seizures. Hippocampal seizures induced all the immediate-early gene proteins in dentate granule cells with differing time-courses. In addition, Krox-24, Fos and Jun D were also induced in somatostatin-containing interneurons throughout the hippocampus and also in a small percentage of parvalbumin-containing interneurons. Thus, hippocampal seizures induce waves of immediate-early gene protein expression in dentate granule cells and a selective expression of krox-24, Fos and Jun D in hippocampal somatostatin interneurons. These results suggest that biochemical and/or morphological changes occurring in dentate granule cells and somatostatin interneurons after seizures may be regulated by immediate-early gene expression, and that these immediate-early gene proteins may be involved in seizure development in the nervous system.

Original languageEnglish
Pages (from-to)119-126
Number of pages8
JournalMolecular Brain Research
Volume13
Issue number1-2
DOIs
Publication statusPublished - 1992
Externally publishedYes

Fingerprint

Immediate-Early Proteins
Immediate-Early Genes
Somatostatin-Secreting Cells
Interneurons
Seizures
Proto-Oncogene Proteins c-fos
Somatostatin
Proteins
Hippocampus
Gene Expression
Parvalbumins
Nervous System

Keywords

  • c-jun
  • Epileptogenesis
  • Fos
  • Fos B
  • jun B
  • jun D
  • Krox 24

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience

Cite this

Induction of immediate-early gene proteins in dentate granule cells and somatostatin interneurons after hippocampal seizures. / Dragunow, M.; Yamada, Norihito; Bilkey, D. K.; Lawlor, P.

In: Molecular Brain Research, Vol. 13, No. 1-2, 1992, p. 119-126.

Research output: Contribution to journalArticle

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