Induction of ICAM-1 and VCAM-1 on the mouse lingual lymphatic endothelium with TNF-α

Kana Iwasawa, Takeshi Kameyama, Hiroyuki Ishikawa, Yoshihiko Sawa

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

This study investigated the TNF-α-induced ICAM-1 and VCAM-1 expression on mouse lingual lymphatic vessels. All podoplanin-positive lymphatic vessels expressed PECAM-1. In the lamina propria mucosae of TNF-α-treated tongue, almost all initial lymphatics expressed ICAM-1. There were initial lymphatics with the VCAM-1 expression and also the vessels without the expression. In the tunica muscularis of TNF-α-treated tongue, collecting lymphatic vessels expressed ICAM-1, but rarely expressed VCAM-1 whereas blood vessels simultaneously expressed ICAM-1 and VCAM-1. The ICAM-1-positive rate increased with TNF-α to 75% from 10% on initial lymphatics, and to 40% from 0% on collecting lymphatic vessels while it increased to 90% from 45% on blood vessels. The VCAM-1-positive rate increased with TNF-α to 30% from 0% on initial lymphatics, and to 5% from 0% on collecting lymphatic vessels while it increased to 75% from 5% on blood vessels. These findings suggest that the lingual lymphatic endothelium has the ability to express ICAM-1, and VCAM-1 to a lesser extent than the ICAM-1 induction with TNF-α, and that the ICAM-1 and VCAM-1 induction predominantly occurs in the initial lymphatics compared with collecting lymphatic vessels.

Original languageEnglish
Pages (from-to)115-120
Number of pages6
JournalActa Histochemica et Cytochemica
Volume41
Issue number5
DOIs
Publication statusPublished - Oct 2008
Externally publishedYes

Fingerprint

Lymphatic Endothelium
Vascular Cell Adhesion Molecule-1
Intercellular Adhesion Molecule-1
Tongue
Lymphatic Vessels
Blood vessels
Blood Vessels
Mucous Membrane
CD31 Antigens

Keywords

  • ICAM-1
  • Lymphatic endothelium
  • PECAM-1
  • Podoplanin
  • VCAM-1

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Physiology
  • Pathology and Forensic Medicine
  • Histology

Cite this

Induction of ICAM-1 and VCAM-1 on the mouse lingual lymphatic endothelium with TNF-α. / Iwasawa, Kana; Kameyama, Takeshi; Ishikawa, Hiroyuki; Sawa, Yoshihiko.

In: Acta Histochemica et Cytochemica, Vol. 41, No. 5, 10.2008, p. 115-120.

Research output: Contribution to journalArticle

Iwasawa, Kana ; Kameyama, Takeshi ; Ishikawa, Hiroyuki ; Sawa, Yoshihiko. / Induction of ICAM-1 and VCAM-1 on the mouse lingual lymphatic endothelium with TNF-α. In: Acta Histochemica et Cytochemica. 2008 ; Vol. 41, No. 5. pp. 115-120.
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