Abstract
This study investigated the TNF-α-induced ICAM-1 and VCAM-1 expression on mouse lingual lymphatic vessels. All podoplanin-positive lymphatic vessels expressed PECAM-1. In the lamina propria mucosae of TNF-α-treated tongue, almost all initial lymphatics expressed ICAM-1. There were initial lymphatics with the VCAM-1 expression and also the vessels without the expression. In the tunica muscularis of TNF-α-treated tongue, collecting lymphatic vessels expressed ICAM-1, but rarely expressed VCAM-1 whereas blood vessels simultaneously expressed ICAM-1 and VCAM-1. The ICAM-1-positive rate increased with TNF-α to 75% from 10% on initial lymphatics, and to 40% from 0% on collecting lymphatic vessels while it increased to 90% from 45% on blood vessels. The VCAM-1-positive rate increased with TNF-α to 30% from 0% on initial lymphatics, and to 5% from 0% on collecting lymphatic vessels while it increased to 75% from 5% on blood vessels. These findings suggest that the lingual lymphatic endothelium has the ability to express ICAM-1, and VCAM-1 to a lesser extent than the ICAM-1 induction with TNF-α, and that the ICAM-1 and VCAM-1 induction predominantly occurs in the initial lymphatics compared with collecting lymphatic vessels.
| Original language | English |
|---|---|
| Pages (from-to) | 115-120 |
| Number of pages | 6 |
| Journal | Acta Histochemica et Cytochemica |
| Volume | 41 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - Oct 2008 |
| Externally published | Yes |
Fingerprint
Keywords
- ICAM-1
- Lymphatic endothelium
- PECAM-1
- Podoplanin
- VCAM-1
ASJC Scopus subject areas
- Biochemistry
- Cell Biology
- Physiology
- Pathology and Forensic Medicine
- Histology
Cite this
Induction of ICAM-1 and VCAM-1 on the mouse lingual lymphatic endothelium with TNF-α. / Iwasawa, Kana; Kameyama, Takeshi; Ishikawa, Hiroyuki; Sawa, Yoshihiko.
In: Acta Histochemica et Cytochemica, Vol. 41, No. 5, 10.2008, p. 115-120.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Induction of ICAM-1 and VCAM-1 on the mouse lingual lymphatic endothelium with TNF-α
AU - Iwasawa, Kana
AU - Kameyama, Takeshi
AU - Ishikawa, Hiroyuki
AU - Sawa, Yoshihiko
PY - 2008/10
Y1 - 2008/10
N2 - This study investigated the TNF-α-induced ICAM-1 and VCAM-1 expression on mouse lingual lymphatic vessels. All podoplanin-positive lymphatic vessels expressed PECAM-1. In the lamina propria mucosae of TNF-α-treated tongue, almost all initial lymphatics expressed ICAM-1. There were initial lymphatics with the VCAM-1 expression and also the vessels without the expression. In the tunica muscularis of TNF-α-treated tongue, collecting lymphatic vessels expressed ICAM-1, but rarely expressed VCAM-1 whereas blood vessels simultaneously expressed ICAM-1 and VCAM-1. The ICAM-1-positive rate increased with TNF-α to 75% from 10% on initial lymphatics, and to 40% from 0% on collecting lymphatic vessels while it increased to 90% from 45% on blood vessels. The VCAM-1-positive rate increased with TNF-α to 30% from 0% on initial lymphatics, and to 5% from 0% on collecting lymphatic vessels while it increased to 75% from 5% on blood vessels. These findings suggest that the lingual lymphatic endothelium has the ability to express ICAM-1, and VCAM-1 to a lesser extent than the ICAM-1 induction with TNF-α, and that the ICAM-1 and VCAM-1 induction predominantly occurs in the initial lymphatics compared with collecting lymphatic vessels.
AB - This study investigated the TNF-α-induced ICAM-1 and VCAM-1 expression on mouse lingual lymphatic vessels. All podoplanin-positive lymphatic vessels expressed PECAM-1. In the lamina propria mucosae of TNF-α-treated tongue, almost all initial lymphatics expressed ICAM-1. There were initial lymphatics with the VCAM-1 expression and also the vessels without the expression. In the tunica muscularis of TNF-α-treated tongue, collecting lymphatic vessels expressed ICAM-1, but rarely expressed VCAM-1 whereas blood vessels simultaneously expressed ICAM-1 and VCAM-1. The ICAM-1-positive rate increased with TNF-α to 75% from 10% on initial lymphatics, and to 40% from 0% on collecting lymphatic vessels while it increased to 90% from 45% on blood vessels. The VCAM-1-positive rate increased with TNF-α to 30% from 0% on initial lymphatics, and to 5% from 0% on collecting lymphatic vessels while it increased to 75% from 5% on blood vessels. These findings suggest that the lingual lymphatic endothelium has the ability to express ICAM-1, and VCAM-1 to a lesser extent than the ICAM-1 induction with TNF-α, and that the ICAM-1 and VCAM-1 induction predominantly occurs in the initial lymphatics compared with collecting lymphatic vessels.
KW - ICAM-1
KW - Lymphatic endothelium
KW - PECAM-1
KW - Podoplanin
KW - VCAM-1
UR - http://www.scopus.com/inward/record.url?scp=55249107144&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=55249107144&partnerID=8YFLogxK
U2 - 10.1267/ahc.08017
DO - 10.1267/ahc.08017
M3 - Article
C2 - 18989464
AN - SCOPUS:55249107144
VL - 41
SP - 115
EP - 120
JO - Acta Histochemica et Cytochemica
JF - Acta Histochemica et Cytochemica
SN - 0044-5991
IS - 5
ER -