Abstract
Distribution of heat shock protein (HSP) 90α mRNA induction after 10 min of transient global ischemia was investigated in gerbil hippocampus by in situ hybridization. A small amount of HSP90α mRNA was normally present in hippocampal cells and the mRNA was further induced with a peak at 8 h after ischemia. In hippocampal CA1 cells that are vulnerable to ischemia, HSP90α mRNA was continuously induced by 1 day and finally diminished at 2 days. The temporal profile of HSP90α mRNA induction in hippocampal CA1 cells was similar to that of HSP70 mRNA reported previously, suggesting a cooperative role of HSP90α with other HSPs after ischemia.
| Original language | English |
|---|---|
| Pages (from-to) | 121-125 |
| Number of pages | 5 |
| Journal | Brain Research |
| Volume | 621 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Sep 3 1993 |
| Externally published | Yes |
Keywords
- Cerebral ischemia
- Gerbil
- Heat shock protein 90
- In situ hybridization
ASJC Scopus subject areas
- Neuroscience(all)
- Molecular Biology
- Clinical Neurology
- Developmental Biology
Fingerprint Dive into the research topics of 'Induction of HSP90α heat shock mRNA after transient global ischemia in gerbil hippocampus'. Together they form a unique fingerprint.
Cite this
Kawagoe, J. I., Abe, K., Aoki, M., & Kogure, K. (1993). Induction of HSP90α heat shock mRNA after transient global ischemia in gerbil hippocampus. Brain Research, 621(1), 121-125. https://doi.org/10.1016/0006-8993(93)90306-8