TY - JOUR
T1 - Induction of HSP90α heat shock mRNA after transient global ischemia in gerbil hippocampus
AU - Kawagoe, Jun ichi
AU - Abe, Koji
AU - Aoki, Masashi
AU - Kogure, Kyuya
N1 - Funding Information:
This work was partly supported by a Monbusho Grant 01044018 and 03404028, a grant from the Ministry of Welfare and Health of Japan, and the Kowa Life Science Foundation. The authors would like to express their appreciation to Mrs. M. Matsumoto and Miss N. Igarashi for their excellent technical assistance.
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1993/9/3
Y1 - 1993/9/3
N2 - Distribution of heat shock protein (HSP) 90α mRNA induction after 10 min of transient global ischemia was investigated in gerbil hippocampus by in situ hybridization. A small amount of HSP90α mRNA was normally present in hippocampal cells and the mRNA was further induced with a peak at 8 h after ischemia. In hippocampal CA1 cells that are vulnerable to ischemia, HSP90α mRNA was continuously induced by 1 day and finally diminished at 2 days. The temporal profile of HSP90α mRNA induction in hippocampal CA1 cells was similar to that of HSP70 mRNA reported previously, suggesting a cooperative role of HSP90α with other HSPs after ischemia.
AB - Distribution of heat shock protein (HSP) 90α mRNA induction after 10 min of transient global ischemia was investigated in gerbil hippocampus by in situ hybridization. A small amount of HSP90α mRNA was normally present in hippocampal cells and the mRNA was further induced with a peak at 8 h after ischemia. In hippocampal CA1 cells that are vulnerable to ischemia, HSP90α mRNA was continuously induced by 1 day and finally diminished at 2 days. The temporal profile of HSP90α mRNA induction in hippocampal CA1 cells was similar to that of HSP70 mRNA reported previously, suggesting a cooperative role of HSP90α with other HSPs after ischemia.
KW - Cerebral ischemia
KW - Gerbil
KW - Heat shock protein 90
KW - In situ hybridization
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U2 - 10.1016/0006-8993(93)90306-8
DO - 10.1016/0006-8993(93)90306-8
M3 - Article
C2 - 8221063
AN - SCOPUS:0027317841
VL - 621
SP - 121
EP - 125
JO - Molecular Brain Research
JF - Molecular Brain Research
SN - 0006-8993
IS - 1
ER -