Induction of differentiation of human myeloid leukemia cells by jasmonates, plant hormones

Y. Ishii, Hiromasa Kiyota, S. Sakai, Y. Honma

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Some regulators of plant growth and differentiation have been shown to induce the differentiation of several human myeloid leukemia cells, and might be effective as differentiation inducers to control acute myelogenous leukemia cells. In this study, the growth-inhibiting and differentiation-inducing effects of jasmonates on human myeloid leukemia cells were examined. Several myeloid leukemia cells were cultured with methyl jasmonate (MJ) and its derivatives. Cell differentiation was determined by nitroblue tetrazolium-reducing activity, morphological changes, α-naphthyl acetate esterase activity and expression of differentiation-associated surface antigens. MJ induced both monocytic and granulocytic differentiation of HL-60 cells. MJ activated mitogen-activated protein kinase (MAPK) in the cells before causing myelomonocytic differentiation. MAPK activation was necessary for MJ-induced differentiation, since PD98059, an inhibitor of MAPK kinase, suppressed the differentiation induced by MJ. MJ also induced the differentiation of other human leukemia cell lines. Introduction of a double bond at the 4,5-position greatly enhanced the differentiation-inducing activity of MJ. MJ and its derivatives potently induce the differentiation of some myelomonocytic leukemia cells. One novel derivative is a particularly promising therapeutic agent for the treatment of leukemia.

Original languageEnglish
Pages (from-to)1413-1419
Number of pages7
JournalLeukemia
Volume18
Issue number8
DOIs
Publication statusPublished - Aug 2004
Externally publishedYes

Fingerprint

Myeloid Leukemia
Plant Growth Regulators
Myeloid Cells
Leukemia
Mitogen-Activated Protein Kinases
Acetylesterase
Nitroblue Tetrazolium
methyl jasmonate
HL-60 Cells
Mitogen-Activated Protein Kinase Kinases
Surface Antigens
Acute Myeloid Leukemia
Cell Differentiation
Cell Line
Growth

Keywords

  • Differentiation
  • Differentiation therapy
  • Jasmonate
  • Myeloid leukemia
  • Plant hormone

ASJC Scopus subject areas

  • Hematology
  • Cancer Research

Cite this

Induction of differentiation of human myeloid leukemia cells by jasmonates, plant hormones. / Ishii, Y.; Kiyota, Hiromasa; Sakai, S.; Honma, Y.

In: Leukemia, Vol. 18, No. 8, 08.2004, p. 1413-1419.

Research output: Contribution to journalArticle

Ishii, Y. ; Kiyota, Hiromasa ; Sakai, S. ; Honma, Y. / Induction of differentiation of human myeloid leukemia cells by jasmonates, plant hormones. In: Leukemia. 2004 ; Vol. 18, No. 8. pp. 1413-1419.
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